Fragilis / IFITM3 (Protein | Antibody | cDNA Clone | ELISA Kit)

All Fragilis / IFITM3 reagents are produced in house and quality controlled, including 42 Fragilis / IFITM3 Gene, 1 Fragilis / IFITM3 Lysate, 1 Fragilis / IFITM3 Protein, 2 Fragilis / IFITM3 qPCR. All Fragilis / IFITM3 reagents are ready to use.

Fragilis / IFITM3 Protein (1)

Fragilis / IFITM3 cDNA Clone (42)

NM_021034.2
BC006794

In lentiviral vector

NM_001136124.1

Fragilis / IFITM3 Lysate (1)

Fragilis / IFITM3 Related Research Area

Fragilis / IFITM3 Background

Interferon-induced transmembrane protein 3 (IFITM3) belongs to the CD225 family. To replicate, viruses must gain access to the host cell's resources. Interferon (IFN) regulates the actions of a large complement of interferon effector genes (IEGs) that prevent viral replication. The interferon inducible transmembrane protein family members, IFITM1, 2 and 3, are IEGs required for inhibition of influenza A virus, dengue virus, and West Nile virus replication in vitro. IFITM3 is an IFN-induced antiviral protein that mediates cellular innate immunity to at least three major human pathogens, namely influenza A H1N1 virus, West Nile virus (WNV), and dengue virus (WNV), by inhibiting the early step(s) of replication. It is both necessary and sufficient for preventing the emergence of viral genomes from the endosomal pathway. Viral pseudoparticles were inhibited from transferring their contents into the host cell cytosol by IFN, and IFITM3 was required and sufficient for this action. IFITM3 overexpression is sufficient for this phenotype. Moreover, IFITM3 partially resides in late endosomal and lysosomal structures, placing it in the path of invading viruses.

Fragilis / IFITM3 References

  • Tanaka SS, et al. (2005) IFITM/Mil/fragilis family proteins IFITM1 and IFITM3 play distinct roles in mouse primordial germ cell homing and repulsion. Dev Cell. 9(6):745-56.
  • Li D, et al. (2011) KLF4-mediated negative regulation of IFITM3 expression plays a critical role in colon cancer pathogenesis. Clin Cancer Res. 17(11):3558-68.
  • Lu J, et al. (2011) The IFITM proteins inhibit HIV-1 infection. J Virol. 85(5):2126-37.