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Человек TNFRSF11A Джин ORF экспрессии кДНК клона плазмиды, N-Myc Метка

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Human TNFRSF11A Информация о продукте «Клон cDNA»
Gene_bank_ref_id:NM_003839.2
Размер кДНК:1851bp
Описание кДНК:Full length Clone DNA of Homo sapiens tumor necrosis factor receptor superfamily, member 11a, NFKB activator with N terminal Myc tag.
Синоним гена:FEO, OFE, ODFR, OSTS, PDB2, RANK, CD265, OPTB7, TRANCER, LOH18CR1
Виды:Human
переносчик:pCMV3-SP-N-Myc
Plasmid:
Участок рестрикции:
Последовательность меток:Myc Tag Sequence: GAGCAGAAACTCATCTCAGAAGAGGATCTG
Описание последовательности:
Sequencing primers:T7(TAATACGACTCACTATAGGG) BGH(TAGAAGGCACAGTCGAGG)
Promoter:Enhanced CMV mammalian cell promoter
Application:Stable or Transient mammalian expression
Antibiotic in E.coli:Kanamycin
Antibiotic in mammalian cell:Hygromycin
Shipping_carrier:Each tube contains lyophilized plasmid.
Склад:The lyophilized plasmid can be stored at room temperature for three months.
Myc Tag Info

A myc tag can be used in many different assays that require recognition by an antibody. If there is no antibody against the studied protein, adding a myc-tag allows one to follow the protein with an antibody against the Myc epitope. Examples are cellular localization studies by immunofluorescence or detection by Western blotting.

The peptide sequence of the myc-tag is: N-EQKLISEEDL-C (1202 Da). It can be fused to the C-terminus and the N-terminus of a protein. It is advisable not to fuse the tag directly behind the signal peptide of a secretory protein, since it can interfere with translocation into the secretory pathway.

Человек TNFRSF11A Джин ORF экспрессии кДНК клона плазмиды, N-Myc Метка on other vectors
Человек TNFRSF11A Джин ORF экспрессии кДНК клона плазмиды, C-GFPSpark МеткаHG16078-ACGRBS16764
Человек TNFRSF11A Джин ORF экспрессии кДНК клона плазмиды, C-OFPSpark МеткаHG16078-ACRRBS16764
Человек TNFRSF11A Джин ORF экспрессии кДНК клона плазмиды, C-Flag МеткаHG16078-CFRBS14711
Человек TNFRSF11A Джин ORF экспрессии кДНК клона плазмиды, C-His МеткаHG16078-CHRBS14711
Человек TNFRSF11A Джин ORF экспрессии кДНК клона плазмиды, C-Myc МеткаHG16078-CMRBS14711
Человек TNFRSF11A Джин ORF экспрессии кДНК клона плазмиды, C-HA МеткаHG16078-CYRBS14711
Человек TNFRSF11A Джин клон кДНК в вектор клонированияHG16078-GRBS5132
Человек TNFRSF11A Джин ORF экспрессии кДНК клона плазмиды, N-Flag МеткаHG16078-NFRBS14711
Человек TNFRSF11A Джин ORF экспрессии кДНК клона плазмиды, N-His МеткаHG16078-NHRBS14711
Человек TNFRSF11A Джин ORF экспрессии кДНК клона плазмиды, N-Myc МеткаHG16078-NMRBS14711
Человек TNFRSF11A Джин ORF экспрессии кДНК клона плазмиды, N-HA МеткаHG16078-NYRBS14711
Человек TNFRSF11A Джин ORF экспрессии кДНК клона плазмидыHG16078-UTRBS14711
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Фон

TNFRSF11A is a member of the TNF-receptor superfamily. In mouse, it is also known as CD265. TNFRSF11A contains 4 TNFR-Cys repeats and is widely expressed with high levels in skeletal muscle, thymus, liver, colon, small intestine and adrenal gland. It is an essential mediator for osteoclast and lymph node development. TNFRSF11A and its ligand are important regulators of the interaction between T cells and dendritic cells. It can interact with various TRAF family proteins, through which this receptor induces the activation of NF-kappa B and MAPK8/JNK. Defects in TNFRSF11A can cause familial expansile osteolysis (FEO). FEO is a rare autosomal dominant bone disorder characterized by focal areas of increased bone remodeling. Defects in TNFRSF11A also can cause Paget disease of bone type 2 (PDB2). PDB2 is a bone-remodeling disorder with clinical similarities to FEO. Defects in TNFRSF11A are the cause of osteopetrosis autosomal recessive type 7 which characterized by abnormally dense bone, due to defective resorption of immature bone.

Ссылки
  • Darnay B G, et al. (1998) Characterization of the intracellular domain of receptor activator of NF-kappaB (RANK). Interaction with tumor necrosis factor receptor-associated factors and activation of NF-kappab and c-Jun N-terminal kinase. J Biol Chem. 273(32):20551-5.
  • Darnay B G, et al. (1999) Activation of NF-kappaB by RANK requires tumor necrosis factor receptor-associated factor (TRAF) 6 and NF-kappaB-inducing kinase. Identification of a novel TRAF6 interaction motif. J Biol Chem. 274(12):7724-31.
  • Galibert L, et al. (1998) The involvement of multiple tumor necrosis factor receptor (TNFR)-associated factors in the signaling mechanisms of receptor activator of NF-kappaB, a member of the TNFR superfamily. J Biol Chem. 273(51):34120-7.
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    Каталог: HG16078-NM
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