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Человек SNCA/alpha-Synuclein Джин ORF экспрессии кДНК клона плазмиды, N-HA Метка

ПаспортОбзорыСвязанные продуктыПротоколы
Human SNCA Информация о продукте «Клон cDNA»
Gene_bank_ref_id:NM_000345.3
Размер кДНК:423bp
Описание кДНК:Full length Clone DNA of Homo sapiens synuclein, alpha (non A4 component of amyloid precursor) with N terminal HA tag.
Синоним гена:PD1, NACP, PARK1, PARK4, MGC110988, SNCA
Виды:Human
переносчик:pCMV3-N-HA
Plasmid:
Участок рестрикции:
Последовательность меток:HA Tag Sequence: TATCCTTACGACGTGCCTGACTACGCC
Описание последовательности:
Sequencing primers:T7(TAATACGACTCACTATAGGG) BGH(TAGAAGGCACAGTCGAGG)
Promoter:Enhanced CMV mammalian cell promoter
Application:Stable or Transient mammalian expression
Antibiotic in E.coli:Kanamycin
Antibiotic in mammalian cell:Hygromycin
Shipping_carrier:Each tube contains lyophilized plasmid.
Склад:The lyophilized plasmid can be stored at room temperature for three months.
HA Tag Info

Human influenza hemagglutinin (HA) is a surface glycoprotein required for the infectivity of the human virus. The HA tag is derived from the HA-molecule corresponding to amino acids 98-106 has been extensively used as a general epitope tag in expression vectors. Many recombinant proteins have been engineered to express the HA tag, which does not appear to interfere with the bioactivity or the biodistribution of the recombinant protein. This tag facilitates the detection, isolation, and purification of the proteins.

The actual HA tag is as follows: 5' TAC CCA TAC GAT GTT CCA GAT TAC GCT 3' or 5' TAT CCA TAT GAT GTT CCA GAT TAT GCT 3' The amino acid sequence is: YPYDVPDYA.

Человек SNCA/alpha-Synuclein Джин ORF экспрессии кДНК клона плазмиды, N-HA Метка on other vectors
Человек SNCA/alpha-Synuclein Джин ORF экспрессии кДНК клона плазмиды, C-GFPSpark МеткаHG12093-ACGRBS15396
Человек SNCA/alpha-Synuclein Джин ORF экспрессии кДНК клона плазмиды, C-OFPSpark МеткаHG12093-ACRRBS15396
Человек SNCA/alpha-Synuclein Джин ORF экспрессии кДНК клона плазмиды, N-GFPSpark МеткаHG12093-ANGRBS15396
Человек SNCA/alpha-Synuclein Джин ORF экспрессии кДНК клона плазмиды, N-OFPSpark МеткаHG12093-ANRRBS15396
Человек SNCA/alpha-Synuclein Джин ORF экспрессии кДНК клона плазмиды, C-Flag МеткаHG12093-CFRBS13343
Человек SNCA/alpha-Synuclein Джин ORF экспрессии кДНК клона плазмиды, C-His МеткаHG12093-CHRBS13343
Человек SNCA/alpha-Synuclein Джин ORF экспрессии кДНК клона плазмиды, C-Myc МеткаHG12093-CMRBS13343
Человек SNCA/alpha-Synuclein Джин ORF экспрессии кДНК клона плазмиды, C-HA МеткаHG12093-CYRBS13343
Человек SNCA/alpha-Synuclein Джин клон кДНК в вектор клонированияHG12093-GRBS5132
Человек SNCA/alpha-Synuclein Джин ORF экспрессии кДНК клона плазмиды, N-Flag МеткаHG12093-NFRBS13343
Человек SNCA/alpha-Synuclein Джин ORF экспрессии кДНК клона плазмиды, N-His МеткаHG12093-NHRBS13343
Человек SNCA/alpha-Synuclein Джин ORF экспрессии кДНК клона плазмиды, N-Myc МеткаHG12093-NMRBS13343
Человек SNCA/alpha-Synuclein Джин ORF экспрессии кДНК клона плазмиды, N-HA МеткаHG12093-NYRBS13343
Человек SNCA/alpha-Synuclein Джин ORF экспрессии кДНК клона плазмидыHG12093-UTRBS13343
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Фон

Alpha-Synuclein (alpha-Syn), also known as NACP or SNCA, exists as at least two structural isoforms: one is helix-rich, membrane-bound form that both the N- and C-terminal regions of alpha-synuclein are tightly associated with membranes and the other is disordered, cytosolic form. Synuclein is found predominantly in the presynaptic termini, in both free or membrane-bound forms. SNCA is extensively localized in nucleus of neurons. It has been shown that alpha-Synuclein was highly expressed in the mitochondria in olfactory bulb, hippocampus, striatum, and thalamus, where the cytosolic alpha-Synuclein was also rich. Normally the unstructured soluble type of alpha-synuclein can aggregate to form insoluble fibrils in pathological conditions characterized by Lewy bodies, such as Parkinson's disease, dementia with Lewy bodies and multiple system atrophy. SNCA abnormality and mitochondrial deficiency are two major changes in the brain of patients with Parkinson's disease (PD). In addition, alpha-synuclein is an abundant component of Lewy bodies in sporadic Parkinson's disease and diffuse Lewy body disease.

Ссылки
  • Arima K, et al. (1998) Immunoelectron-microscopic demonstration of NACP / alpha-synuclein-epitopes onthe filamentous component of Lewy bodies in Parkinson's disease and in dementia with Lewy bodies. Brain Res. 808 (1): 93-100.
  • Arima K, et al. (1998) NACP / alpha-synuclein immunoreactivity in fibrillary components of neuronal and oligodendroglial cytoplasmic inclusions in the pontine nuclei in multiple system atrophy. Acta Neuropathol. 96 (5): 439-44.
  • Lee HJ, et al. (2001) Membrane-bound alpha-Synuclein Has a High Aggregation Propensity and the Ability to Seed the Aggregation of the Cytosolic Form. The Journal of Biological Chemistry. 277: 671-8.
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    Каталог: HG12093-NY
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    Наличие2-3 weeks
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