After search, choose a molecule or a kind of categories listed in the left to narrow down your filter. If you have any problems, please contact us!

Быстрый заказ

Text Size:AAA

Человек S100A8/MRP-8 Джин ORF экспрессии кДНК клона плазмиды, C-HA Метка

ПаспортОбзорыСвязанные продуктыПротоколы
Human S100A8 Информация о продукте «Клон cDNA»
Gene_bank_ref_id:NM_002964.3
Размер кДНК:282bp
Описание кДНК:Full length Clone DNA of Homo sapiens S100 calcium binding protein A8 with C terminal HA tag.
Синоним гена:P8, MIF, NIF, CAGA, CFAG, CGLA, L1Ag, MRP8, CP-10, MA387, 60B8AG, S100A8
Виды:Human
переносчик:pCMV3-C-HA
Plasmid:pCMV3-S100A8-HA
Участок рестрикции:KpnI + XbaI (6kb + 0.32kb)
Последовательность меток:HA Tag Sequence: TATCCTTACGACGTGCCTGACTACGCC
Описание последовательности:Identical with the Gene Bank Ref. ID sequence.
Sequencing primers:T7(TAATACGACTCACTATAGGG) BGH(TAGAAGGCACAGTCGAGG)
Promoter:Enhanced CMV mammalian cell promoter
Application:Stable or Transient mammalian expression
Antibiotic in E.coli:Kanamycin
Antibiotic in mammalian cell:Hygromycin
Shipping_carrier:Each tube contains lyophilized plasmid.
Склад:The lyophilized plasmid can be stored at room temperature for three months.
Human S100A8 Gene Plasmid Map
Human S100A8 natural ORF mammalian expression plasmid, C-HA tag
HA Tag Info

Human influenza hemagglutinin (HA) is a surface glycoprotein required for the infectivity of the human virus. The HA tag is derived from the HA-molecule corresponding to amino acids 98-106 has been extensively used as a general epitope tag in expression vectors. Many recombinant proteins have been engineered to express the HA tag, which does not appear to interfere with the bioactivity or the biodistribution of the recombinant protein. This tag facilitates the detection, isolation, and purification of the proteins.

The actual HA tag is as follows: 5' TAC CCA TAC GAT GTT CCA GAT TAC GCT 3' or 5' TAT CCA TAT GAT GTT CCA GAT TAT GCT 3' The amino acid sequence is: YPYDVPDYA.

Человек S100A8/MRP-8 Джин ORF экспрессии кДНК клона плазмиды, C-HA Метка on other vectors
Человек S100A8/MRP-8 Джин ORF экспрессии кДНК клона плазмиды, C-GFPSpark МеткаHG11138-ACGRBS15396
Человек S100A8/MRP-8 Джин ORF экспрессии кДНК клона плазмиды, C-OFPSpark МеткаHG11138-ACRRBS15396
Человек S100A8/MRP-8 Джин ORF экспрессии кДНК клона плазмиды, C-Flag МеткаHG11138-CFRBS13343
Человек S100A8/MRP-8 Джин ORF экспрессии кДНК клона плазмиды, C-His МеткаHG11138-CHRBS13343
Человек S100A8/MRP-8 Джин ORF экспрессии кДНК клона плазмиды, C-Myc МеткаHG11138-CMRBS13343
Человек S100A8/MRP-8 Джин ORF экспрессии кДНК клона плазмиды, C-Myc МеткаHG11138-CMRBS13343
Человек S100A8/MRP-8 Джин ORF экспрессии кДНК клона плазмиды, C-HA МеткаHG11138-CYRBS13343
Человек S100A8/MRP-8 Джин клон кДНК в вектор клонированияHG11138-MRBS5132
Человек S100A8/MRP-8 Джин ORF экспрессии кДНК клона плазмиды, N-Flag МеткаHG11138-NFRBS13343
Человек S100A8/MRP-8 Джин ORF экспрессии кДНК клона плазмиды, N-His МеткаHG11138-NHRBS13343
Человек S100A8/MRP-8 Джин ORF экспрессии кДНК клона плазмиды, N-Myc МеткаHG11138-NMRBS13343
Человек S100A8/MRP-8 Джин ORF экспрессии кДНК клона плазмиды, N-HA МеткаHG11138-NYRBS13343
Человек S100A8/MRP-8 Джин ORF экспрессии кДНК клона плазмидыHG11138-UTRBS13343
 Узнайте больше о векторов экспрессии,
Product nameProduct name
Фон

S100A8 is a member of the S100 protein family containing 2EF-hand calcium-binding motifs. S100 proteins are involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. Altered expression of S100A8 protein is associated with various diseases and cancers. S100A8 may have an immunoregulatory role by contributing to the regulation of fetal-maternal interactions. It may play a protective role and its absence may allow infiltration by maternal cells, a process eventually manifesting as resorption. The heterodimeric S100 protein complex S100A8/A9 which has been shown to be involved in inflammatory and neoplastic disorders. The complex can induce cell proliferation, or apoptosis, inflammation, collagen synthesis, and cell migration. S100A8/A9 has emerged as important pro-inflammatory mediator in acute and chronic inflammation. More recently, increased S100A8 and S100A9 levels were also detected in various human cancers, presenting abundant expression in neoplastic tumor cells as well as infiltrating immune cells. On the one hand, S100A8/A9 is a powerful apoptotic agent produced by immune cells, making it a very fascinating tool in the battle against cancer. It spears the risk to induce auto-immune response and may serve as a lead compound for cancer-selective therapeutics. In contrast, S100A8/A9 expression in cancer cells has also been associated with tumor development, cancer invasion or metastasis. Altogether, its expression and potential cytokine-like function in inflammation and in cancer suggests that S100A8/A9 may play a key role in inflammation-associated cancer.

Ссылки
  • Passey RJ, et al. (1999) S100A8: emerging functions and regulation. J Leukoc Biol. 66(4): 549-56.
  • Gebhardt C, et al. (2006) S100A8 and S100A9 in inflammation and cancer. Biochem Pharmacol. 72(11): 1622-31.
  • Halayko AJ, et al. (2009) S100A8/A9: a mediator of severe asthma pathogenesis and morbidity? Can J Physiol Pharmacol. 87(10): 743-55.
  • Ghavami S, et al. (2009) S100A8/A9: a Janus-faced molecule in cancer therapy and tumorgenesis. Eur J Pharmacol. 625(1-3): 73-83.
  • Ha YS, et al. (2010) mRNA Expression of S100A8 as a Prognostic Marker for Progression of Non-Muscle-Invasive Bladder Cancer. Korean J Urol. 51(1): 15-20.
  • Size / Price
    Каталог: HG11138-CY
    Цена по прейскуранту: 
    Цена:      (You Save: )
    Размер:
    Количество:+-
    НаличиеIn Stock
    Запрос по оптовому заказуДобавить в корзину
    Contact Us
    Изображения
    • Human S100A8 natural ORF mammalian expression plasmid, C-HA tag
      All information of our products is subject to change without notice. Please refer to COA enclosed in shipped package for the newest information.
      Внимание: все продукты «ПРЕДНАЗНАЧЕНЫ ИСКЛЮЧИТЕЛЬНО ДЛЯ ИССЛЕДОВАНИЙ И НЕ ПРЕДНАЗНАЧЕНЫ ДЛЯ ДИАГНОСТИКИ ИЛИ ТЕРАПЕВТИЧЕСКОГО ЛЕЧЕНИЯ».