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Человек S100A10 Джин ORF экспрессии кДНК клона плазмиды, C-HA Метка

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Human S100A10 Информация о продукте «Клон cDNA»
Gene_bank_ref_id:NM_002966.2
Размер кДНК:294bp
Описание кДНК:Full length Clone DNA of Homo sapiens S100 calcium binding protein A10 with C terminal HA tag.
Синоним гена:42C, P11, p10, GP11, ANX2L, CAL1L, CLP11, Ca[1], ANX2LG, MGC111133, S100A10
Виды:Human
переносчик:pCMV3-C-HA
Plasmid:
Участок рестрикции:
Последовательность меток:HA Tag Sequence: TATCCTTACGACGTGCCTGACTACGCC
Описание последовательности:
Sequencing primers:T7(TAATACGACTCACTATAGGG) BGH(TAGAAGGCACAGTCGAGG)
Promoter:Enhanced CMV mammalian cell promoter
Application:Stable or Transient mammalian expression
Antibiotic in E.coli:Kanamycin
Antibiotic in mammalian cell:Hygromycin
Shipping_carrier:Each tube contains lyophilized plasmid.
Склад:The lyophilized plasmid can be stored at room temperature for three months.
HA Tag Info

Human influenza hemagglutinin (HA) is a surface glycoprotein required for the infectivity of the human virus. The HA tag is derived from the HA-molecule corresponding to amino acids 98-106 has been extensively used as a general epitope tag in expression vectors. Many recombinant proteins have been engineered to express the HA tag, which does not appear to interfere with the bioactivity or the biodistribution of the recombinant protein. This tag facilitates the detection, isolation, and purification of the proteins.

The actual HA tag is as follows: 5' TAC CCA TAC GAT GTT CCA GAT TAC GCT 3' or 5' TAT CCA TAT GAT GTT CCA GAT TAT GCT 3' The amino acid sequence is: YPYDVPDYA.

Человек S100A10 Джин ORF экспрессии кДНК клона плазмиды, C-HA Метка on other vectors
Человек S100A10 Джин ORF экспрессии кДНК клона плазмиды, C-GFPSpark МеткаHG11144-ACGRBS15400
Человек S100A10 Джин ORF экспрессии кДНК клона плазмиды, C-OFPSpark МеткаHG11144-ACRRBS15400
Человек S100A10 Джин ORF экспрессии кДНК клона плазмиды, N-GFPSpark МеткаHG11144-ANGRBS15400
Человек S100A10 Джин ORF экспрессии кДНК клона плазмиды, N-OFPSpark МеткаHG11144-ANRRBS15400
Человек S100A10 Джин ORF экспрессии кДНК клона плазмиды, C-Flag МеткаHG11144-CFRBS13340
Человек S100A10 Джин ORF экспрессии кДНК клона плазмиды, C-His МеткаHG11144-CHRBS13340
Человек S100A10 Джин ORF экспрессии кДНК клона плазмиды, C-Myc МеткаHG11144-CMRBS13340
Человек S100A10 Джин ORF экспрессии кДНК клона плазмиды, C-HA МеткаHG11144-CYRBS13340
Человек S100A10 Джин клон кДНК в вектор клонированияHG11144-MRBS5130
Человек S100A10 Джин ORF экспрессии кДНК клона плазмиды, C-Flag МеткаHG11144-M-FRBS13340
Человек S100A10 Джин ORF экспрессии кДНК клона плазмиды, N-Flag МеткаHG11144-NFRBS13340
Человек S100A10 Джин ORF экспрессии кДНК клона плазмиды, N-His МеткаHG11144-NHRBS13340
Человек S100A10 Джин ORF экспрессии кДНК клона плазмиды, N-Myc МеткаHG11144-NMRBS13340
Человек S100A10 Джин ORF экспрессии кДНК клона плазмиды, N-HA МеткаHG11144-NYRBS13340
Человек S100A10 Джин ORF экспрессии кДНК клона плазмидыHG11144-UTRBS13340
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Фон

S100 protein is a family of low molecular weight protein found in vertebrates characterized by two EF-hand calcium-binding motifs. There are at least 21 different S100 proteins, and the name is derived from the fact that the protein is 100% soluble in ammonium sulfate at neutral pH. Most S100 proteins are disulfide-linked homodimer, and is normally present in cells derived from the neural crest, chondrocytes, macrophages, dendritic cells, etc. S100 proteins have been implicated in a variety of intracellular and extracellular functions. They are involved in regulation of protein phosphorylation, transcription factors, the dynamics of cytoskeleton constituents, enzyme activities, cell growth and differentiation, and the inflammatory response.  
Protein S100-A10, also known as Calpactin I light chain, Cellular ligand of annexin II, S100 calcium-binding protein A10, p10 protein, p11, ANX2LG and S100A10, is a member of the S100 family of small, dimeric EF hand-type Ca(2+)-binding proteins that generally modulate cellular target proteins in response to intracellular Ca(2+) signals. In contrast to all other S100 proteins, S100A10 is Ca(2+) insensitive because of amino acid replacements in its Ca(2+)-binding loops that lock the protein in a permanently active state. S100A10 forms a heterotetramer with annexin IIH and promotes carcinoma invasion and metastasis by plasminogen activation. S100A10 and annexin II contribute to the aggressive characteristics of anaplastic carcinoma, while playing a constitutive role in papillary carcinoma. S100A10 induces the dimerization of ANXA2 / p36, it may function as a regulator of protein phosphorylation in that the ANXA2 monomer is the preferred target of tyrosine-specific kinase. S100A10 functions as a linker tethering certain transmembrane proteins to annexin A2 thereby assisting their traffic to the plasma membrane and/or their firm anchorage at certain membrane sites.

Ссылки
  • Gebhardt, C. et al., 2006, Biochem Pharmacol. 72 (11):1622-31.
  • Ito,Y. et al., 2007, Anticancer Res. 27 (4C):2679-83.
  • Svenningsson,P. et al., 2007, Curr Opin Pharmacol  7 (1):27-32.
  • Rescher,U. et al., 2008, Pflugers Arch. 455 (4):575-82.
  • Nonaka, D. et al., 2008, J. Cutan. Pathol. 35 (11): 1014-9.
  • Lim, SY. et al., 2008,  J Immunol. 181 (8): 5627-36.
  • Heibeck TH. et al., 2009, J. Proteome Res. 8:3852-61.
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    Каталог: HG11144-CY
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    Наличие2-3 weeks
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