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Человек PTX3/Pentraxin 3/TSG-14 Джин ORF экспрессии кДНК клона плазмиды, C-HA Метка

  • other Green fluorescent protein / GFP Gene Plasmid Map 5612
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Человек PTX3 Информация о продукте «Клон cDNA»
Gene_bank_ref_id:NM_002852
Размер кДНК:1188 bp
Описание кДНК:Full length Clone DNA of Homo sapiens pentraxin-related gene, rapidly induced by IL-1 betaV with C terminal HA tag.
Синоним гена:TSG-14, TNFAIP5, PTX3
Виды:Human
переносчик:pCMV3-C-HA
Plasmid:pCMV3-PTX3-HA
Участок рестрикции:KpnI + XbaI(6kb+1.19kb)
Последовательность меток:HA Tag Sequence: TATCCTTACGACGTGCCTGACTACGCC
Описание последовательности:Identical with the Gene Bank Ref. ID sequence.
Sequencing primers:T7(TAATACGACTCACTATAGGG) BGH(TAGAAGGCACAGTCGAGG)
( We provide with PTX3 qPCR primers for gene expression analysis, HP101610 )
Promoter:Enhanced CMV mammalian cell promoter
Application:Stable or Transient mammalian expression
Antibiotic in E.coli:Kanamycin
Antibiotic in mammalian cell:Hygromycin
Shipping_carrier:Each tube contains lyophilized plasmid.
Склад:The lyophilized plasmid can be stored at room temperature for three months.
HA Tag Info

Human influenza hemagglutinin (HA) is a surface glycoprotein required for the infectivity of the human virus. The HA tag is derived from the HA-molecule corresponding to amino acids 98-106 has been extensively used as a general epitope tag in expression vectors. Many recombinant proteins have been engineered to express the HA tag, which does not appear to interfere with the bioactivity or the biodistribution of the recombinant protein. This tag facilitates the detection, isolation, and purification of the proteins.

The actual HA tag is as follows: 5' TAC CCA TAC GAT GTT CCA GAT TAC GCT 3' or 5' TAT CCA TAT GAT GTT CCA GAT TAT GCT 3' The amino acid sequence is: YPYDVPDYA.

Человек PTX3/Pentraxin 3/TSG-14 Джин ORF экспрессии кДНК клона плазмиды, C-HA Метка on other vectors
Человек PTX3/Pentraxin 3/TSG-14 Джин ORF экспрессии кДНК клона плазмиды, C-GFPSpark МеткаHG12082-ACGRBS16760
Человек PTX3/Pentraxin 3/TSG-14 Джин ORF экспрессии кДНК клона плазмиды, C-OFPSpark МеткаHG12082-ACRRBS15400
Человек PTX3/Pentraxin 3/TSG-14 Джин ORF экспрессии кДНК клона плазмиды, C-Flag МеткаHG12082-CFRBS13340
Человек PTX3/Pentraxin 3/TSG-14 Джин ORF экспрессии кДНК клона плазмиды, C-His МеткаHG12082-CHRBS13340
Человек PTX3/Pentraxin 3/TSG-14 Джин ORF экспрессии кДНК клона плазмиды, C-Myc МеткаHG12082-CMRBS13340
Человек PTX3/Pentraxin 3/TSG-14 Джин ORF экспрессии кДНК клона плазмиды, C-HA МеткаHG12082-CYRBS13340
Человек PTX3/Pentraxin 3/TSG-14 Джин клон кДНК в вектор клонированияHG12082-GRBS5130
Человек PTX3/Pentraxin 3/TSG-14 Джин ORF экспрессии кДНК клона плазмиды, N-Flag МеткаHG12082-NFRBS13340
Человек PTX3/Pentraxin 3/TSG-14 Джин ORF экспрессии кДНК клона плазмиды, N-His МеткаHG12082-NHRBS13340
Человек PTX3/Pentraxin 3/TSG-14 Джин ORF экспрессии кДНК клона плазмиды, N-Myc МеткаHG12082-NMRBS13340
Человек PTX3/Pentraxin 3/TSG-14 Джин ORF экспрессии кДНК клона плазмиды, N-HA МеткаHG12082-NYRBS13340
Человек PTX3/Pentraxin 3/TSG-14 Джин ORF экспрессии кДНК клона плазмидыHG12082-UTRBS13340
 Узнайте больше о векторов экспрессии,
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Фон

Pentraxin-related protein PTX3, also known as Tumor necrosis factor alpha-induced protein 5, Tumor necrosis factor-inducible gene 14 protein, TSG-14, PTX3 and TNFAIP5, is a secreted protein which contains one pentaxin domain. PTX3 plays a role in the regulation of innate resistance to pathogens, inflammatory reactions, possibly clearance of self-components and female fertility. Pentraxins are a family of evolutionarily conserved multifunctional pattern-recognition proteins characterized by a cyclic multimeric structure. Based on the primary structure of the subunit, the pentraxins are divided into two groups: short pentraxins and long pentraxins. C-reactive protein (CRP) and serum amyloid P-component (SAP) are the two short pentraxins. The prototype protein of the long pentraxin group is pentraxin 3 (PTX3). CRP and SAP are produced primarily in the liver in response to IL-6, while PTX3 is produced by a variety of tissues and cells and in particular by innate immunity cells in response to proinflammatory signals and Toll-like receptor (TLR) engagement. PTX3 is essential in female fertility by acting as a nodal point for the assembly of the cumulus oophorus hyaluronan-rich extracellular matrix. PTX3 interacts with several ligands, including growth factors, extracellular matrix components and selected pathogens, playing a role in complement activation and facilitating pathogen recognition by phagocytes, acting as a predecessor of antibodies. PTX3 may also contribute to the pathogenesis of atherosclerosis.

Ссылки
  • Rolph,M.S. et al., 2002, Arterioscler Thromb Vasc Biol. 22 (5):e10-4.
  • Mantovani A., et al., 2003, Vaccine. 21:S43-S47.
  • Luchetti,M.M. et al., 2004, Clin Exp Rheumatol. 22 (3):S66-72.
  • Mantovani, A. et al., 2006, Vascul Pharmacol. 45 (5):326-30.
  • Inforzato A., et al., 2008, J. Biol. Chem. 283:10147-61.
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    Каталог: HG12082-CY
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