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Человек Nicastrin/NCSTN Джин ORF экспрессии кДНК клона плазмиды

ПаспортОбзорыСвязанные продуктыПротоколы
Human NCSTN Информация о продукте «Клон cDNA»
Gene_bank_ref_id:NM_015331.2
Размер кДНК:2130bp
Описание кДНК:Full length Clone DNA of Homo sapiens nicastrin.
Синоним гена:APH2, KIAA0253, RP11-517F10.1, NCSTN
Виды:Human
переносчик:pCMV3-untagged
Plasmid:pCMV3-NCSTN
Участок рестрикции:KpnI + XbaI (6.1kb + 2.13kb)
Последовательность меток:
Описание последовательности:Identical with the Gene Bank Ref. ID sequence.
Sequencing primers:T7(TAATACGACTCACTATAGGG) BGH(TAGAAGGCACAGTCGAGG)
Promoter:Enhanced CMV mammalian cell promoter
Application:Stable or Transient mammalian expression
Antibiotic in E.coli:Ampicilin
Antibiotic in mammalian cell:Hygromycin
Shipping_carrier:Each tube contains lyophilized plasmid.
Склад:The lyophilized plasmid can be stored at room temperature for three months.
Человек Nicastrin/NCSTN Джин ORF экспрессии кДНК клона плазмиды on other vectors
Человек Nicastrin/NCSTN Джин ORF экспрессии кДНК клона плазмиды, C-GFPSpark МеткаHG11183-ACGRBS16764
Человек Nicastrin/NCSTN Джин ORF экспрессии кДНК клона плазмиды, C-OFPSpark МеткаHG11183-ACRRBS16764
Человек Nicastrin/NCSTN Джин ORF экспрессии кДНК клона плазмиды, C-Flag МеткаHG11183-CFRBS14711
Человек Nicastrin/NCSTN Джин ORF экспрессии кДНК клона плазмиды, C-His МеткаHG11183-CHRBS14711
Человек Nicastrin/NCSTN Джин ORF экспрессии кДНК клона плазмиды, C-Myc МеткаHG11183-CMRBS14711
Человек Nicastrin/NCSTN Джин ORF экспрессии кДНК клона плазмиды, C-HA МеткаHG11183-CYRBS14711
Человек Nicastrin/NCSTN Джин клон кДНК в вектор клонированияHG11183-MRBS5132
Человек Nicastrin/NCSTN Джин ORF экспрессии кДНК клона плазмиды, N-Flag МеткаHG11183-NFRBS14711
Человек Nicastrin/NCSTN Джин ORF экспрессии кДНК клона плазмиды, N-His МеткаHG11183-NHRBS14711
Человек Nicastrin/NCSTN Джин ORF экспрессии кДНК клона плазмиды, N-Myc МеткаHG11183-NMRBS14711
Человек Nicastrin/NCSTN Джин ORF экспрессии кДНК клона плазмиды, N-HA МеткаHG11183-NYRBS14711
Человек Nicastrin/NCSTN Джин ORF экспрессии кДНК клона плазмидыHG11183-UTRBS14711
 Узнайте больше о векторов экспрессии,
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Фон

Nicastrin (NCST, or NCT), a single-pass membrane glycoprotein that harbors a large extracellular domain, is an essential component of the gamma-secretase complex. Several lines of evidence indicate that the members of these complexes could also contribute to the control of cell death. NCT controls cell death via phosphoinositide 3-kinase/Akt and p53-dependent pathways and that this function remains independent of the activity and molecular integrity of the gamma-secretase complexes. Increasing evidences have shown that Nicastrin/NCSTN plays a crucial role in gamma-cleavage of the amyloid precursor protein (APP). The glycoprotein Nicastrin is an essential component of the gamma-secretase complex, a high molecular weight complex which also contains the presenilin proteins, Aph-1 and Pen-2. The gamma-secretase complex is not only involved in APP processing but also in the processing of an increasing number of other type I integral membrane proteins. As the largest subunit of the gamma-secretase complex, Nicastrin plays a crucial role in its activation. Inhibition of NCSTN demonstrated an altered gamma-cleavage activity, suggesting its potential implication in developing Alzheimer's disease (AD). In addition, Nicastrin can function to maintain epithelial to mesenchymal transition during breast cancer progression. Anti-nicastrin polyclonal and monoclonal antibodies were able to decrease notch1 and vimentin expression and reduced the invasive capacity of breast cancer cells in vitro.

Ссылки
  • He G, et al. (2007) Degradation of nicastrin involves both proteasome and lysosome. J Neurochem. 101(4): 982-92.
  • Hayashi I, et al. (2009) Single chain variable fragment against nicastrin inhibits the gamma-secretase activity. J Biol Chem. 284(41): 27838-47.
  • Ma Z, et al. (2009) Association between promoter polymorphisms of the nicastrin gene and sporadic Alzheimer's disease in North Chinese Han population. Neurosci Lett. 458(3): 136-9.
  • Pardossi-Piquard R, et al. (2009) p53-dependent control of cell death by nicastrin: lack of requirement for presenilin-dependent gamma-secretase complex. J Neurochem. 109(1): 225-37.
  • Filipovi? A, et al. (2011) Biological and clinical implications of nicastrin expression in invasive breast cancer. Breast Cancer Res Treat. 125(1): 43-53.
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    Каталог: HG11183-UT
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