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Человек OLR1/LOX1 Джин ORF экспрессии кДНК клона плазмиды, C-Myc Метка

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Human OLR1 Информация о продукте «Клон cDNA»
Gene_bank_ref_id:NM_002543.3
Размер кДНК:822bp
Описание кДНК:Full length Clone DNA of Homo sapiens oxidized low density lipoprotein (lectin-like) receptor 1 with C terminal Myc tag.
Синоним гена:LOX1, CLEC8A, SCARE1
Виды:Human
переносчик:pCMV3-C-Myc
Plasmid:
Участок рестрикции:
Последовательность меток:Myc Tag Sequence: GAGCAGAAACTCATCTCAGAAGAGGATCTG
Описание последовательности:
Sequencing primers:T7(TAATACGACTCACTATAGGG) BGH(TAGAAGGCACAGTCGAGG)
Promoter:Enhanced CMV mammalian cell promoter
Application:Stable or Transient mammalian expression
Antibiotic in E.coli:Kanamycin
Antibiotic in mammalian cell:Hygromycin
Shipping_carrier:Each tube contains lyophilized plasmid.
Склад:The lyophilized plasmid can be stored at room temperature for three months.
Myc Tag Info

A myc tag is a polypeptide protein tag derived from the c-myc gene product that can be added to a protein using recombinant DNA technology. It can be used for affinity chromatography, then used to separate recombinant, overexpressed protein from wild type protein expressed by the host organism. It can also be used in the isolation of protein complexes with multiple subunits.

A myc tag can be used in many different assays that require recognition by an antibody. If there is no antibody against the studied protein, adding a myc-tag allows one to follow the protein with an antibody against the Myc epitope. Examples are cellular localization studies by immunofluorescence or detection by Western blotting.

The peptide sequence of the myc-tag is: N-EQKLISEEDL-C (1202 Da). It can be fused to the C-terminus and the N-terminus of a protein. It is advisable not to fuse the tag directly behind the signal peptide of a secretory protein, since it can interfere with translocation into the secretory pathway.

Человек OLR1/LOX1 Джин ORF экспрессии кДНК клона плазмиды, C-Myc Метка on other vectors
Человек OLR1/LOX1 Джин ORF экспрессии кДНК клона плазмиды, C-GFPSpark МеткаHG10585-ACGRBS15400
Человек OLR1/LOX1 Джин ORF экспрессии кДНК клона плазмиды, C-OFPSpark МеткаHG10585-ACRRBS15400
Человек OLR1/LOX1 Джин ORF экспрессии кДНК клона плазмиды, C-Flag МеткаHG10585-CFRBS13340
Человек OLR1/LOX1 Джин ORF экспрессии кДНК клона плазмиды, C-His МеткаHG10585-CHRBS13340
Человек OLR1/LOX1 Джин ORF экспрессии кДНК клона плазмиды, C-Myc МеткаHG10585-CMRBS13340
Человек OLR1/LOX1 Джин ORF экспрессии кДНК клона плазмиды, C-HA МеткаHG10585-CYRBS13340
Человек OLR1/LOX1 Джин клон кДНК в вектор клонированияHG10585-MRBS5130
Человек OLR1/LOX1 Джин ORF экспрессии кДНК клона плазмидыHG10585-M-NRBS13340
Человек OLR1/LOX1 Джин ORF экспрессии кДНК клона плазмиды, N-Flag МеткаHG10585-NFRBS13340
Человек OLR1/LOX1 Джин ORF экспрессии кДНК клона плазмиды, N-His МеткаHG10585-NHRBS13340
Человек OLR1/LOX1 Джин ORF экспрессии кДНК клона плазмиды, N-Myc МеткаHG10585-NMRBS13340
Человек OLR1/LOX1 Джин ORF экспрессии кДНК клона плазмиды, N-HA МеткаHG10585-NYRBS13340
Человек OLR1/LOX1 Джин ORF экспрессии кДНК клона плазмидыHG10585-UTRBS13340
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Фон

Oxidized low-density lipoprotein receptor 1 (Ox-LDL receptor 1 or OLR1), also known as lectin-type oxidized LDL receptor 1 (LOX1), is a receptor protein that belongs to the C-type lectin superfamily. LOX1 is a multi-ligand receptor originally identified as the endothelial oxidized LDL receptor. OLR1 / LOX1 was isolated from an aortic endothelial cell, and recently it has been discovered in macrophages and vascular smooth muscle cells in artery vessels. The expression of LOX1 is inducted by inflammatory stimuli and oxidative stimuli. This protein binds, internalizes and degrades oxidized low-density lipoprotein. LOX1 may play an important role in the progression of vulnerable carotid plaque and might regulate vulnerable plaque formation in cooperation with MMPs and TIMP-2. In clinical, LOX1 is thought to be involved in the development of atherosclerotic lesions. 

Ссылки
  • Hinagata J, et al. (2006) Oxidized LDL receptor LOX-1 is involved in neointimal hyperplasia after balloon arterial injury in a rat model. Cardiovasc Res. 69 (1): 263-71.
  • Melan MA, et al. (1994) The LOX1 Gene of Arabidopsis Is Temporally and Spatially Regulated in Germinating Seedlings. Plant Physiol. 105 (1): 385-93.
  • Saito A, et al. (2010) Relationship between lectin-like oxidized low-density lipoprotein receptor 1 expression and preoperative echogenic findings of vulnerable carotid plaque. Acta Neurochir (Wien). 152 (4): 589-95.
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