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Человек WSX-1/IL-27R Джин ORF экспрессии кДНК клона плазмиды, C-HA Метка

ПаспортОбзорыСвязанные продуктыПротоколы
Human IL27RA Информация о продукте «Клон cDNA»
Gene_bank_ref_id:NM_004843.2
Размер кДНК:1911bp
Описание кДНК:Full length Clone DNA of Homo sapiens interleukin 27 receptor, alpha with C terminal HA tag.
Синоним гена:CRL1, TCCR, WSX1, IL27R, zcytor1, IL27RA
Виды:Human
переносчик:pCMV3-C-HA
Plasmid:
Участок рестрикции:
Последовательность меток:HA Tag Sequence: TATCCTTACGACGTGCCTGACTACGCC
Описание последовательности:
Sequencing primers:T7(TAATACGACTCACTATAGGG) BGH(TAGAAGGCACAGTCGAGG)
Promoter:Enhanced CMV mammalian cell promoter
Application:Stable or Transient mammalian expression
Antibiotic in E.coli:Kanamycin
Antibiotic in mammalian cell:Hygromycin
Shipping_carrier:Each tube contains lyophilized plasmid.
Склад:The lyophilized plasmid can be stored at room temperature for three months.
HA Tag Info

Human influenza hemagglutinin (HA) is a surface glycoprotein required for the infectivity of the human virus. The HA tag is derived from the HA-molecule corresponding to amino acids 98-106 has been extensively used as a general epitope tag in expression vectors. Many recombinant proteins have been engineered to express the HA tag, which does not appear to interfere with the bioactivity or the biodistribution of the recombinant protein. This tag facilitates the detection, isolation, and purification of the proteins.

The actual HA tag is as follows: 5' TAC CCA TAC GAT GTT CCA GAT TAC GCT 3' or 5' TAT CCA TAT GAT GTT CCA GAT TAT GCT 3' The amino acid sequence is: YPYDVPDYA.

Человек WSX-1/IL-27R Джин ORF экспрессии кДНК клона плазмиды, C-HA Метка on other vectors
Человек WSX-1/IL-27R Джин ORF экспрессии кДНК клона плазмиды, C-GFPSpark МеткаHG10489-ACGRBS16760
Человек WSX-1/IL-27R Джин ORF экспрессии кДНК клона плазмиды, C-OFPSpark МеткаHG10489-ACRRBS16760
Человек WSX-1/IL-27R Джин ORF экспрессии кДНК клона плазмиды, C-Flag МеткаHG10489-CFRBS14710
Человек WSX-1/IL-27R Джин ORF экспрессии кДНК клона плазмиды, C-His МеткаHG10489-CHRBS14710
Человек WSX-1/IL-27R Джин ORF экспрессии кДНК клона плазмиды, C-Myc МеткаHG10489-CMRBS14710
Человек WSX-1/IL-27R Джин ORF экспрессии кДНК клона плазмиды, C-HA МеткаHG10489-CYRBS14710
Человек WSX-1/IL-27R Джин клон кДНК в вектор клонированияHG10489-GRBS5130
Человек WSX-1/IL-27R Джин ORF экспрессии кДНК клона плазмиды, N-Flag МеткаHG10489-NFRBS14710
Человек WSX-1/IL-27R Джин ORF экспрессии кДНК клона плазмиды, N-His МеткаHG10489-NHRBS14710
Человек WSX-1/IL-27R Джин ORF экспрессии кДНК клона плазмиды, N-Myc МеткаHG10489-NMRBS14710
Человек WSX-1/IL-27R Джин ORF экспрессии кДНК клона плазмиды, N-HA МеткаHG10489-NYRBS14710
Человек WSX-1/IL-27R Джин ORF экспрессии кДНК клона плазмидыHG10489-UTRBS14710
 Узнайте больше о векторов экспрессии,
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Фон

The interleukin-27 receptor is a type I cytokine receptor for interleukin-27. It is a heterodimer composed of the interleukin 27 receptor, alpha subunit and glycoprotein 130. WSX-1/IL-27R, a class I cytokine receptor that is homologous to the β2 chain of the IL-12R in both sequence and structure, is highly expressed by resting/naive CD4+ T cells and CD8+ T cells. WSX-1/IL-27R belongs to the IL-6/IL-12 family of cytokines and induced proliferation of naive CD4(+) T cells and the generation of a Th1-type adaptive immune response. WSX-1/IL-27R functions as a receptor for IL27. IL-27 not only contributes to the development of an adaptive immune response through its action on CD4(+) T cells, it also directly acts on cells of the innate immune system. WSX-1/IL-27R requires IL6ST/gp130 to mediate signal transduction in response to IL27. This signaling system acts through STAT3 and STAT1. It is involved in the regulation of Th1-type immune responses. IL-27R also appears to be involved in innate defense mechanisms. IL27RA is essential for transcriptional activation of STAT1 and for augmenting the induction of T-bet expression during initiation of Th1 cell differentiation.

Ссылки
  • Pflanz S, et al.. (2004) WSX-1 and glycoprotein 130 constitute a signal-transducing receptor for IL-27. J Immunol. 172(4): 2225-31.
  • Yoshida H, et al.. (2001) WSX-1 is required for the initiation of Th1 responses and resistance to L. major infection. Immunity. 215(4): 569-78.
  • Villarino A, et al.. (2003) The IL-27R (WSX-1) is required to suppress T cell hyperactivity during infection. Immunity. 19(5): 645-55.
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    Каталог: HG10489-CY
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    Наличие2-3 weeks
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