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Человек IL18R1 Джин ORF экспрессии кДНК клона плазмиды, C-His Метка

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Human IL18R1 Информация о продукте «Клон cDNA»
Gene_bank_ref_id:NM_003855.2
Размер кДНК:1626bp
Описание кДНК:Full length Clone DNA of Homo sapiens interleukin 18 receptor 1 with C terminal His tag.
Синоним гена:CD218a, IL18RA, IL1RRP, CDw218a, IL-1Rrp, IL18R1
Виды:Human
переносчик:pCMV3-C-His
Plasmid:pCMV3-IL18R1-His
Участок рестрикции:KpnI + XbaI (6kb + 1.67kb)
Последовательность меток:His Tag Sequence: CACCATCACCACCATCATCACCACCATCAC
Описание последовательности:Identical with the Gene Bank Ref. ID sequence.
Sequencing primers:T7(TAATACGACTCACTATAGGG) BGH(TAGAAGGCACAGTCGAGG)
Promoter:Enhanced CMV mammalian cell promoter
Application:Stable or Transient mammalian expression
Antibiotic in E.coli:Kanamycin
Antibiotic in mammalian cell:Hygromycin
Shipping_carrier:Each tube contains lyophilized plasmid.
Склад:The lyophilized plasmid can be stored at room temperature for three months.
Human IL18R1 Gene Plasmid Map
Human IL18R1 natural ORF mammalian expression plasmid, C-His tag
His Tag Info

A polyhistidine-tag is an amino acid motif in proteins that consists of at least five histidine (His) residues, often at the N- or C-terminus of the protein.

Polyhistidine-tags are often used for affinity purification of polyhistidine-tagged recombinant proteins expressed in Escherichia coli and other prokarfyotic expression systems.

Человек IL18R1 Джин ORF экспрессии кДНК клона плазмиды, C-His Метка on other vectors
Человек IL18R1 Джин ORF экспрессии кДНК клона плазмиды, C-GFPSpark МеткаHG11102-ACGRBS16760
Человек IL18R1 Джин ORF экспрессии кДНК клона плазмиды, C-OFPSpark МеткаHG11102-ACRRBS16760
Человек IL18R1 Джин ORF экспрессии кДНК клона плазмиды, C-Flag МеткаHG11102-CFRBS14710
Человек IL18R1 Джин ORF экспрессии кДНК клона плазмиды, C-His МеткаHG11102-CHRBS14710
Человек IL18R1 Джин ORF экспрессии кДНК клона плазмиды, C-Myc МеткаHG11102-CMRBS14710
Человек IL18R1 Джин ORF экспрессии кДНК клона плазмиды, C-HA МеткаHG11102-CYRBS14710
Человек IL18R1 Джин клон кДНК в вектор клонированияHG11102-MRBS5130
Человек IL18R1 Джин ORF экспрессии кДНК клона плазмиды, N-Flag МеткаHG11102-NFRBS14710
Человек IL18R1 Джин ORF экспрессии кДНК клона плазмиды, N-His МеткаHG11102-NHRBS14710
Человек IL18R1 Джин ORF экспрессии кДНК клона плазмиды, N-Myc МеткаHG11102-NMRBS14710
Человек IL18R1 Джин ORF экспрессии кДНК клона плазмиды, N-HA МеткаHG11102-NYRBS14710
Человек IL18R1 Джин ORF экспрессии кДНК клона плазмидыHG11102-UTRBS14710
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Фон

Interleukin-18 receptor 1 (IL18R1) also known as CD218 antigen-like family member A, CDw218a, IL1 receptor-related protein and CD218a, is an interleukin receptor of the immunoglobulin superfamily. IL18R1 is found expressed in lung, leukocytes, spleen, liver, thymus, prostate, small intestine, colon, placenta, and heart, and is absent from brain, skeletal muscle, pancreas, and kidney. High level of expression is found in Hodgkin disease cell lines. This receptor is specifically binds interleukin 18 (IL18), and is essential for IL18 mediated signal transduction. IL18R1 contains 3 Ig-like C2-type (immunoglobulin-like) domains and 1 TIR domain. It is a single-pass type I membrane protein. IFN-alpha and IL12 are reported to induce the expression of this receptor in NK and T cells. The increased expression of IL18R1 may contribute pathogenically to disease and is therefore a potential therapeutic target. The absence of a genetic association in the IL18R1 gene itself suggests regulation from other parts of the genome, or as part of the inflammatory cascade in multiple sclerosis without a prime genetic cause.

Ссылки
  • Nadif R, et al.. (2006) IL18 and IL18R1 polymorphisms, lung CT and fibrosis: A longitudinal study in coal miners. Eur Respir J. 28(6): 1100-5.
  • Haralambieva IH, et al.. (2011) Common SNPs/haplotypes in IL18R1 and IL18 genes are associated with variations in hum oral immunity to smallpox vaccination in Caucasians and African Americans. J Infect Dis. 204(3): 433-41.
  • Hulin-Curtis SL, et al.. (2012) Evaluation of IL18 and IL18R1 polymorphisms: genetic susceptibility to knee osteoarthritis. Int J Immunogenet. 39(2): 106-9.
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