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Человек HRAS Джин ORF экспрессии кДНК клона плазмиды, C-His Метка

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Human HRAS Информация о продукте «Клон cDNA»
Gene_bank_ref_id:NM_001130442.1
Размер кДНК:570bp
Описание кДНК:Full length Clone DNA of Homo sapiens v-Ha-ras Harvey rat sarcoma viral oncogene homolog with C terminal His tag.
Синоним гена:CTLO, HAMSV, HRAS1, K-RAS, N-RAS, RASH1, C-H-RAS, H-RASIDX, C-BAS/HAS, C-HA-RAS1, HRAS
Виды:Human
переносчик:pCMV3-C-His
Plasmid:
Участок рестрикции:
Последовательность меток:His Tag Sequence: CACCATCACCACCATCATCACCACCATCAC
Описание последовательности:
Sequencing primers:T7(TAATACGACTCACTATAGGG) BGH(TAGAAGGCACAGTCGAGG)
Promoter:Enhanced CMV mammalian cell promoter
Application:Stable or Transient mammalian expression
Antibiotic in E.coli:Kanamycin
Antibiotic in mammalian cell:Hygromycin
Shipping_carrier:Each tube contains lyophilized plasmid.
Склад:The lyophilized plasmid can be stored at room temperature for three months.
His Tag Info

A polyhistidine-tag is an amino acid motif in proteins that consists of at least five histidine (His) residues, often at the N- or C-terminus of the protein.

Polyhistidine-tags are often used for affinity purification of polyhistidine-tagged recombinant proteins expressed in Escherichia coli and other prokarfyotic expression systems.

Человек HRAS Джин ORF экспрессии кДНК клона плазмиды, C-His Метка on other vectors
Человек HRAS Джин ORF экспрессии кДНК клона плазмиды, C-GFPSpark МеткаHG12059-ACGRBS15400
Человек HRAS Джин ORF экспрессии кДНК клона плазмиды, C-OFPSpark МеткаHG12059-ACRRBS15400
Человек HRAS Джин ORF экспрессии кДНК клона плазмиды, C-Flag МеткаHG12059-CFRBS13340
Человек HRAS Джин ORF экспрессии кДНК клона плазмиды, C-His МеткаHG12059-CHRBS13340
Человек HRAS Джин ORF экспрессии кДНК клона плазмиды, C-Myc МеткаHG12059-CMRBS13340
Человек HRAS Джин ORF экспрессии кДНК клона плазмиды, C-HA МеткаHG12059-CYRBS13340
Человек HRAS Джин клон кДНК в вектор клонированияHG12059-GRBS5130
Человек HRAS Джин ORF экспрессии кДНК клона плазмиды, N-Flag МеткаHG12059-NFRBS13340
Человек HRAS Джин ORF экспрессии кДНК клона плазмиды, N-His МеткаHG12059-NHRBS13340
Человек HRAS Джин ORF экспрессии кДНК клона плазмиды, N-Myc МеткаHG12059-NMRBS13340
Человек HRAS Джин ORF экспрессии кДНК клона плазмиды, N-HA МеткаHG12059-NYRBS13340
Человек HRAS Джин ORF экспрессии кДНК клона плазмидыHG12059-UTRBS13340
 Узнайте больше о векторов экспрессии,
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Фон

HRas, also known as HRAS, belongs to the small GTPase superfamily, Ras family and is widely expressed. It functions in signal transduction pathways. HRas can bind GTP and GDP, and they have intrinsic GTPase activity. It undergoes a continuous cycle of de- and re-palmitoylation, which regulates its rapid exchange between the plasma membrane and the Golgi apparatus. Defects in HRAS are the cause of faciocutaneoskeletal syndrome (FCSS). FCSS is arare condition characterized by prenatally increased growth, postnatal growth deficiency, mental retardation, distinctive facial appearance, cardiovascular abnormalities, tumor predisposition, skin and musculoskeletal abnormalities. Defects in HRAS also can cause congenital myopathy with excess of muscle spindles. HRAS deficiency may be a cause of susceptibility to Hurthle cell thyroid carcinoma. It has been shown that defects in HRAS can cause susceptibility to bladder cancer which is a malignancy originating in tissues of the urinary bladder. It often presents with multiple tumors appearing at different times and at different sites in the bladder. Most bladder cancers are transitional cell carcinomas. They begin in cells that normally make up the inner lining of the bladder. Other types of bladder cancer include squamous cell carcinoma (cancer that begins in thin, flat cells) and adenocarcinoma (cancer that begins in cells that make and release mucus and other fluids). Bladder cancer is a complex disorder with both genetic and environmental influences. Defects in HRAS are the cause of oral squamous cell carcinoma.

Ссылки
  • Schulten HJ, et al. (2011) Mutational screening of RET, HRAS, KRAS, NRAS, BRAF, AKT1, and CTNNB1 in medullary thyroid carcinoma. Anticancer Res. 31(12):4179-83.
  • Gripp KW, et al. (2011) Molecular confirmation of HRAS p.G12S in siblings with Costello syndrome. Am J Med Genet A. 155A(9):2263-8.
  • Na KY, et al. (2012) Allelic loss of susceptibility loci and the occurrence of BRAF and RAS mutations in patients with familial non-medullary thyroid cancer. J Surg Oncol. 105(1):10-4.
  • Membrino A, et al. (2011) G4-DNA formation in the HRAS promoter and rational design of decoy oligonucleotides for cancer therapy. PLoS One. 6(9):e24421.
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    Каталог: HG12059-CH
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    Количество:+-
    Наличие2-3 weeks
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