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Человек HER2 / ErbB2 Белок

  • Human HER2 / ErbB2 Protein
ПаспортОбзорыСвязанные продуктыПротоколы
Человек ERBB2 Информация о продуктах-белках
Синоним:CD340,HER-2,HER-2/neu,HER2,MLN 19,MLN19,NEU,NGL,TKR1
Строение белка:A DNA sequence encoding the human ERBB2 (NP_004439.2) (Met1-Thr652) was expressed with five amino acids (DDDDK) at the C-terminus.
Виды:Human
Хозяин экспрессии:Human Cells
Форма и доставка:In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.
Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.
Человек ERBB2 Тестирование в рамках контроля качества белков
Чистота:> 95 % as determined by SDS-PAGE.
Биологическая активность:1.Measured by its binding ability in a functional ELISA.
2.Immobilized human ErbB2 (Cat:10004-HCCH) at 10μg/mL (100μL/well) can bind herceptin ,the EC50 of herceptin is 7-90ng/mL.
Эндотоксин:< 1.0 EU per μg protein as determined by the LAL method.
Стабильность:Samples are stable for up to twelve months from date of receipt at -70℃
Прогнозируемый N-конец:Thr 23
Молекулярная масса:The recombinant human ERBB2 consists 636 amino acids and predicts a molecular mass of 70 kDa.
Состав:Lyophilized from sterile PBS, pH 7.4.
1. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
2. Please contact us for any concerns or special requirements.
Человек ERBB2 Руководство по использованию белков
Склад:Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Реконструкция:A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.
Человек ERBB2 Protein SDS-PAGE

ERBB2 Связанные пути

Other ERBB2 Recombinant Protein Products
HER2/ERBB2 Фон

Epidermal growth factor receptor 2 (HER2), also known as ErbB2, NEU, and CD340, is a type I membrane glycoprotein, and belongs to the epidermal growth factor (EGF) receptor family. HER2 protein cannot bind growth factors due to the lacking of ligand binding domain of its own and autoinhibited constitutively. However, HER2 forms a heterodimer with other ligand-bound EGF receptor family members, therefore stabilizes ligand binding and enhances kinase-mediated activation of downstream molecules. HER2 plays a key role in development, cell proliferation and differentiation. HER2 gene has been reported to associate with malignancy and a poor prognosis in numerous carcinomas, including breast, prostate, ovarian, lung cancers and so on.

Immune Checkpoint   Immunotherapy   Cancer Immunotherapy   Targeted Therapy

Человек HER2/ERBB2 Ссылки
  • Krawczyk N, et al. (2009) HER2 status on persistent disseminated tumor cells after adjuvant therapy may differ from initial HER2 status on primary tumor. Anticancer Res. 29(10): 4019-24.
  • Product nameProduct name
    Size / Price
    Каталог: 10004-HCCH-50
    Цена по прейскуранту: 
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    Datasheet & Documentation

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        All information of our products is subject to change without notice. Please refer to COA enclosed in shipped package for the newest information.
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