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Человек Ephrin-A4/EFNA4 Джин ORF экспрессии кДНК клона плазмиды, N-HA Метка

ПаспортОбзорыСвязанные продуктыПротоколы
Human EFNA4 Информация о продукте «Клон cDNA»
Gene_bank_ref_id:NM_005227
Размер кДНК:606bp
Описание кДНК:Full length Clone DNA of Homo sapiens ephrin-A4 with N terminal HA tag.
Синоним гена:LERK4
Виды:Human
переносчик:pCMV3-SP-N-HA
Plasmid:
Участок рестрикции:
Последовательность меток:HA Tag Sequence: TATCCTTACGACGTGCCTGACTACGCC
Описание последовательности:
Sequencing primers:T7(TAATACGACTCACTATAGGG) BGH(TAGAAGGCACAGTCGAGG)
Promoter:Enhanced CMV mammalian cell promoter
Application:Stable or Transient mammalian expression
Antibiotic in E.coli:Kanamycin
Antibiotic in mammalian cell:Hygromycin
Shipping_carrier:Each tube contains lyophilized plasmid.
Склад:The lyophilized plasmid can be stored at room temperature for three months.
HA Tag Info

Human influenza hemagglutinin (HA) is a surface glycoprotein required for the infectivity of the human virus. The HA tag is derived from the HA-molecule corresponding to amino acids 98-106 has been extensively used as a general epitope tag in expression vectors. Many recombinant proteins have been engineered to express the HA tag, which does not appear to interfere with the bioactivity or the biodistribution of the recombinant protein. This tag facilitates the detection, isolation, and purification of the proteins.

The actual HA tag is as follows: 5' TAC CCA TAC GAT GTT CCA GAT TAC GCT 3' or 5' TAT CCA TAT GAT GTT CCA GAT TAT GCT 3' The amino acid sequence is: YPYDVPDYA.

Человек Ephrin-A4/EFNA4 Джин ORF экспрессии кДНК клона плазмиды, N-HA Метка on other vectors
Человек Ephrin-A4/EFNA4 Джин ORF экспрессии кДНК клона плазмиды, C-GFPSpark МеткаHG12087-ACGRBS15396
Человек Ephrin-A4/EFNA4 Джин ORF экспрессии кДНК клона плазмиды, C-OFPSpark МеткаHG12087-ACRRBS15396
Человек Ephrin-A4/EFNA4 Джин ORF экспрессии кДНК клона плазмиды, C-Flag МеткаHG12087-CFRBS13343
Человек Ephrin-A4/EFNA4 Джин ORF экспрессии кДНК клона плазмиды, C-His МеткаHG12087-CHRBS13343
Человек Ephrin-A4/EFNA4 Джин ORF экспрессии кДНК клона плазмиды, C-Myc МеткаHG12087-CMRBS13343
Человек Ephrin-A4/EFNA4 Джин ORF экспрессии кДНК клона плазмиды, C-HA МеткаHG12087-CYRBS13343
Человек Ephrin-A4/EFNA4 Джин клон кДНК в вектор клонированияHG12087-GRBS5132
Человек Ephrin-A4/EFNA4 Джин ORF экспрессии кДНК клона плазмиды, N-Flag МеткаHG12087-NFRBS13343
Человек Ephrin-A4/EFNA4 Джин ORF экспрессии кДНК клона плазмиды, N-His МеткаHG12087-NHRBS13343
Человек Ephrin-A4/EFNA4 Джин ORF экспрессии кДНК клона плазмиды, N-Myc МеткаHG12087-NMRBS13343
Человек Ephrin-A4/EFNA4 Джин ORF экспрессии кДНК клона плазмиды, N-HA МеткаHG12087-NYRBS13343
Человек Ephrin-A4/EFNA4 Джин ORF экспрессии кДНК клона плазмидыHG12087-UTRBS13343
 Узнайте больше о векторов экспрессии,
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Фон

EPH-related receptor tyrosine kinase ligand 4 (Ephrin-A4) also known as EFNA4, is a member of the Ephrin family. The Eph family receptor interacting proteins (ephrins) are a family of proteins that serve as the ligands of the Eph receptor, which compose the largest known subfamily of receptor protein-tyrosine kinases (RTKs). Eph/ephrin interactions are implicated in axon guidance, neural crest cell migration, establishment of segmental boundaries, and formation of angiogenic capillary plexi. Ephrin subclasses are further distinguished by their mode of attachment to the plasma membrane: ephrin-A ligands bind EphA receptors and are anchored to the plasma membrane via a glycosylphosphatidylinositol (GPI) linkage, whereas ephrin-B ligands bind EphB receptors and are anchored via a transmembrane domain. An exception is the EphA4 receptor, which binds both subclasses of ephrins. Ephrin-A4/EFNA4 functions as a cell surface GPI-bound ligand for Eph receptor, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development.

Ссылки
  • Aasheim HC, et al. (2000) A splice variant of human ephrin-A4 encodes a soluble molecule that is secreted by activated human B lymphocytes. Blood. 95(1): 221-30.
  • Moss A, et al. (2005) Ephrin-A4 inhibits sensory neurite outgrowth and is regulated by neonatal skin wounding. Eur J Neurosci. 22(10): 2413-21.
  • Cerretti DP, et al. (1998) Characterization of the genes for mouse LERK-3/Ephrin-A3 (Epl3), mouse LERK-4/Ephrin-A4 (Epl4), and human LERK-6/Ephrin-A2 (EPLG6): conservation of intron/exon structure. Genomics. 47(1): 131-5.
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    Каталог: HG12087-NY
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