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Человек Contactin 2/CNTN2 Джин ORF экспрессии кДНК клона плазмиды, C-His Метка

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Human CNTN2 Информация о продукте «Клон cDNA»
Gene_bank_ref_id:NM_005076.2
Размер кДНК:3123bp
Описание кДНК:Full length Clone DNA of Homo sapiens contactin 2 (axonal) with C terminal His tag.
Синоним гена:AXT, TAX, TAX1, TAG-1, FLJ42746, MGC157722, DKFZp781D102, CNTN2
Виды:Human
переносчик:pCMV3-C-His
Plasmid:
Участок рестрикции:
Последовательность меток:His Tag Sequence: CACCATCACCACCATCATCACCACCATCAC
Описание последовательности:
Sequencing primers:T7(TAATACGACTCACTATAGGG) BGH(TAGAAGGCACAGTCGAGG)
Promoter:Enhanced CMV mammalian cell promoter
Application:Stable or Transient mammalian expression
Antibiotic in E.coli:Kanamycin
Antibiotic in mammalian cell:Hygromycin
Shipping_carrier:Each tube contains lyophilized plasmid.
Склад:The lyophilized plasmid can be stored at room temperature for three months.
His Tag Info

A polyhistidine-tag is an amino acid motif in proteins that consists of at least five histidine (His) residues, often at the N- or C-terminus of the protein.

Polyhistidine-tags are often used for affinity purification of polyhistidine-tagged recombinant proteins expressed in Escherichia coli and other prokarfyotic expression systems.

Человек Contactin 2/CNTN2 Джин ORF экспрессии кДНК клона плазмиды, C-His Метка on other vectors
Человек Contactin 2/CNTN2 Джин ORF экспрессии кДНК клона плазмиды, C-GFPSpark МеткаHG10457-ACGRBS22240
Человек Contactin 2/CNTN2 Джин ORF экспрессии кДНК клона плазмиды, C-OFPSpark МеткаHG10457-ACRRBS22240
Человек Contactin 2/CNTN2 Джин ORF экспрессии кДНК клона плазмиды, C-Flag МеткаHG10457-CFRBS20190
Человек Contactin 2/CNTN2 Джин ORF экспрессии кДНК клона плазмиды, C-His МеткаHG10457-CHRBS20190
Человек Contactin 2/CNTN2 Джин ORF экспрессии кДНК клона плазмиды, C-Myc МеткаHG10457-CMRBS20190
Человек Contactin 2/CNTN2 Джин ORF экспрессии кДНК клона плазмиды, C-HA МеткаHG10457-CYRBS20190
Человек Contactin 2/CNTN2 Джин клон кДНК в вектор клонированияHG10457-MRBS5130
Человек Contactin 2/CNTN2 Джин ORF экспрессии кДНК клона плазмиды, N-Flag МеткаHG10457-NFRBS20190
Человек Contactin 2/CNTN2 Джин ORF экспрессии кДНК клона плазмиды, N-His МеткаHG10457-NHRBS20190
Человек Contactin 2/CNTN2 Джин ORF экспрессии кДНК клона плазмиды, N-Myc МеткаHG10457-NMRBS20190
Человек Contactin 2/CNTN2 Джин ORF экспрессии кДНК клона плазмиды, N-HA МеткаHG10457-NYRBS20190
Человек Contactin 2/CNTN2 Джин ORF экспрессии кДНК клона плазмидыHG10457-UTRBS20190
 Узнайте больше о векторов экспрессии,
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Фон

Contactins are a subgroup of molecules belonging to the immunoglobulin superfamily that are expressed exclusively in the nervous system. The subgroup consists of six members: Contactin-1, Contactin-2(TAG-1), Contactin-3(BIG-1), BIG-2, Contactin-5(NB-2) and NB-3. Since their identification in the late 1980s, Contactin-1 and Contactin-2 have been studied extensively. Axonal expression and the neurite extension activity of Contactin-1 and Contactin-2 attracted researchers to study the function of these molecules in axon guidance during development. Contactin-1 and Contactin-2 have come to be known as the principal molecules in the function and maintenance of myelinated neurons. In contrast, the function of the other four members of this subgroup remained unknown until recently. Contactin-2, also known as CNTN2, is a glycosylphosphatidylinositol (GPI)-anchored neuronal membrane protein that functions as a cell adhesion molecule. The human, rat, and chicken Contactin-2 are alternatively known as TAX1 (transiently-expressed axonal glycoprotein), TAG1 (transient axonal glycoprotein), and axonin-1, respectively. Human Contactin-2 shares approximately 91% and 75% amino acid sequence identity with rat and chicken Contactin-2, respectively. Contactin-2 is expressed by a subset of neuronal populations in the developing central nervous system (CNS) and peripheral nervous system (PNS). Contactin-2 is also expressed by oligodendrocytes and Schwann cells, which are myelinating glial cells of the CNS and PNS, respectively. Contactin-2 may play a role in the formation of axon connections in the developing nervous system. Contactin-2 is also involved in glial tumorigenesis and may provide a potential target for therapeutic intervention. During embryonic development, Contactin-2 interacts either in a homophilic, or heterophilic fashion with various transmembrane proteins.

Ссылки
  • Kyriakopoulou K, et al. (2002) A combination of chain and neurophilic migration involving the adhesion molecule TAG-1 in the caudal medulla. Development 129 (2):287-96.
  • Traka M, et al. (2002) The neuronal adhesion protein TAG-1 is expressed by Schwann cells and oligodendrocytes and is localized to the juxtaparanodal region of myelinated fibers. J Neurosci. 22(8):3016-24.
  • Traka M, et al. (2003) Association of TAG-1 with Caspr2 is essential for the molecular organization of juxtaparanodal regions of myelinated fibers. J Cell Biol. 162(6):1161-72.
  • Soares S, et al. (2005) Neuronal and glial expression of the adhesion molecule TAG-1 is regulated after peripheral nerve lesion or central neurodegeneration of adult nervous system. Eur J Neurosci. 21(5):1169-80.
  • Derfuss T, et al. (2009) Contactin-2/TAG-1-directed autoimmunity is identified in multiple sclerosis patients and mediates gray matter pathology in animals. Proc Natl Acad Sci U S A. 106(20):8302-7.
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    Каталог: HG10457-CH
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