STX8, also known as syntaxin 8, directly interacts with HECTd3. STX8 forms the SNARE complex with syntaxin 7, vti1b and endobrevin. STX8 belongs to the syntaxin family. Members of this family are key molecules implicated in diverse vesicle docking and membrane fusion events. STX8 physically interacts with cystic fibrosis transmembrane conductance regulator (CFTR): recombinant syntaxin 8 binds CFTR in vitro and both proteins co-immunoprecipitate in HT29 cells. Syntaxin 8 regulates CFTR-mediated currents in chinese hamster ovary (CHO) cells stably expressing CFTR and syntaxin 8. STX8 contributes to the regulation of CFTR trafficking and chloride channel activity by the SNARE machinery.
- Steegmaier M. et al., 1999, J Biol Chem. 273 (51): 34171-9.
- Thoreau V. et al., 1999, Biochem Biophys Res Commun. 257 (2): 577-83.
- Zhang L. et al., 2009, Cell Mol Neurobiol. 29 (1): 115-21.
- Bilan F. et al., 2004, J Cell Sci. 117 (10): 1923-35.