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Cystatin C / CST3 Антитело, Кроличье моноклональное антитело

  • Cystatin C / CST3 Antibody, Rabbit MAb, Immunohistochemistry
  • Cystatin C / CST3 Antibody, Rabbit MAb, Immunohistochemistry
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Крыса CST3 Информация о продуктах-антителах
Иммуноген:Recombinant Rat Cystatin C / CST3 protein (Catalog#80040-R08H)
Clone ID:001
Тип Ig:Rabbit IgG
Концентрация:
Эндотоксин:
Состав:0.2 μm filtered solution in PBS
Подготовка:This antibody was obtained from a rabbit immunized with purified, recombinant Rat Cystatin C / CST3 (rR Cystatin C / CST3; Catalog#80040-R08H; P14841-1; Met1-Ala140).
Крыса CST3 Antibody IHC Application Image
Cystatin C / CST3 Antibody, Rabbit MAb, Immunohistochemistry
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Caption:
Immunochemical staining of rat CST3 in rat brain with rabbit monoclonal antibody (5 µg/mL, formalin-fixed paraffin embedded sections).
Cystatin C / CST3 Antibody, Rabbit MAb, Immunohistochemistry
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Caption:
Immunochemical staining of rat CST3 in rat kidney with rabbit monoclonal antibody (5 µg/mL, formalin-fixed paraffin embedded sections).
Other CST3 Antibody Products
Cystatin C / CST3 Фон

Cystatin C, also known as Cystatin-3 (CST3) is a secreted type 2 cysteine protease inhibitor synthesized in all nucleated cells, has been proposed as a replacement for serum creatinine for the assessment of renal function, particularly to detect small reductions in glomerular filtration rate. The mature, active form of human cystatin C is a single non-glycosylated polypeptide chain consisting of 120 amino acid residues, with a molecular mass of 13,343-13,359 Da, and containing four characteristic disulfide-paired cysteine residues. Cystatin C is a low-molecular-weight protein which has been proposed as a marker of renal function that could replace creatinine. Indeed, the concentration of Cystatin C is mainly determined by glomerular filtration and is particularly of interest in clinical settings where the relationship between creatinine production and muscle mass impairs the clinical performance of creatinine. Since the last decade, numerous studies have evaluated its potential use in measuring renal function in various populations. More recently, other potential developments for its clinical use have emerged. In almost all the clinical studies, Cystatin C demonstrated a better diagnostic accuracy than serum creatinine in discriminating normal from impaired kidney function, but controversial results have been obtained by comparing this protein with other indices of kidney disease, especially serum creatinine-based equations, such as early atherosclerosis, Alzheimer's dementia, vascular aneurysms, hyperhomocysteinaemia and other neurodegenerative diseases. Cystatin C could be a useful clinical tool to identify HIV-infected persons. In addition, its expression is up-regulated in malignance of certain tumor progression.

Крыса Cystatin C / CST3 Ссылки
  • Mares J, et al. (2003) Use of cystatin C determination in clinical diagnostics. Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 147(2): 177-80.
  • Mussap M, et al. (2004) Biochemistry and clinical role of human cystatin C. Crit Rev Clin Lab Sci. 41(5-6): 467-550.
  • Sronie-Vivien S, et al. (2008) Cystatin C: current position and future prospects. Clin Chem Lab Med. 46(12): 1664-86.
  • Taglieri N, et al. (2009) Cystatin C and cardiovascular risk. Clin Chem. 55(11): 1932-43.
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