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Cathepsin D / CTSD Антитело, Кроличье моноклональное антитело

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Human CTSD Информация о продуктах-антителах
Иммуноген:Recombinant Human Cathepsin D / CTSD protein (Catalog#12517-H08H)
Clone ID:010
Тип Ig:Rabbit IgG
Концентрация:
Эндотоксин:
Состав:0.2 μm filtered solution in PBS with 5% trehalose
Подготовка:This antibody was obtained from a rabbit immunized with purified, recombinant Human Cathepsin D / CTSD (rh Cathepsin D / CTSD; Catalog#12517-H08H; P07339; Met1-Leu412).
Human CTSD Руководство по использованию антител
Специфика:Human Cathepsin D / CTSD
No cross-reactivity in ELISA with
Mouse CTSD
Human CTSA
Human CTSB
Human CTSL
Human BACE1
Заявление:WB, IHC-P

WB: 2-10 μg/mL

IHC-P: 1-10 μg/mL

Склад:This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free.
Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Human CTSD Antibody WB Application Image
Human CTSD Antibody IHC Application Image
Cathepsin D / CTSD Antibody, Rabbit MAb, Immunohistochemistry
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Caption:
Immunochemical staining of human CTSD in human cirrhosis with rabbit monoclonal antibody (3 µg/mL, formalin-fixed paraffin embedded sections).
Cathepsin D / CTSD Antibody, Rabbit MAb, Immunohistochemistry
[Щелкните, чтобы увеличить изображение]
Caption:
Immunochemical staining of human CTSD in human cirrhosis with rabbit monoclonal antibody (3 µg/mL, formalin-fixed paraffin embedded sections).
Cathepsin D / CTSD Antibody, Rabbit MAb, Immunohistochemistry
[Щелкните, чтобы увеличить изображение]
Caption:
Immunochemical staining of human CTSD in human lung cancer with rabbit monoclonal antibody (3 µg/mL, formalin-fixed paraffin embedded sections).
Cathepsin D / CTSD Antibody, Rabbit MAb, Immunohistochemistry
[Щелкните, чтобы увеличить изображение]
Caption:
Immunochemical staining of human CTSD in human lung cancer with rabbit monoclonal antibody (3 µg/mL, formalin-fixed paraffin embedded sections).
Other CTSD Antibody Products
Cathepsin D/CTSD Фон

Cathepsin D (CTSD), a well known lysosomal aspartyl protease and belongs to the peptidase C1 family, which is a normal and major component of lysosomes, and is found in almost all cells and tissues of mammals. Its mostly described function is intracellular catabolism in lysosomal compartments, other physiological effect include hormone and antigen processing. Cathepsin D has a specificity similar to but narrower than that of pepsin A. Cathepsin D plays an important role in the degradation of proteins, the generation of bioactive proteins, antigen processing, etc. Among different role in cell physiology, a new function of this enzyme is examined. Cathepsin D is an important regulator of apoptotic pathways in cells. It acts at different stage of intrinsic and extrinsic pathway of apoptosis. In addition, CTSD secreted from human prostate carcinoma cells are responsible for the generation of angiostatin, a potent endogenous inhibitor of angiogenesis, suggesting its contribution to the prevention of tumor growth and angiogenesis-dependent growth of metastases.

Human Cathepsin D/CTSD Ссылки
  • Fusek M, et al. (2005) Dual role of cathepsin D: ligand and protease. Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 149(1): 43-50.
  • Minarowska A, et al. (2007) Regulatory role of cathepsin D in apoptosis. Folia Histochem Cytobiol. 45(3): 159-63.
  • Zaidi N, et al. (2008) Cathepsin D: a cellular roadmap. Biochem Biophys Res Commun. 376(1): 5-9.
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    Каталог: 12517-R010-50
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