Cadherin 17 / CDH17 (Protein | Antibody | cDNA Clone | ELISA Kit)

All Cadherin 17 / CDH17 reagents are produced in house and quality controlled, including 8 Cadherin 17 / CDH17 Antibody, 52 Cadherin 17 / CDH17 Gene, 1 Cadherin 17 / CDH17 IP Kit, 3 Cadherin 17 / CDH17 Lysate, 3 Cadherin 17 / CDH17 Protein, 3 Cadherin 17 / CDH17 qPCR. All Cadherin 17 / CDH17 reagents are ready to use.

Cadherin 17 / CDH17 Protein (3)

Cadherin 17 / CDH17 Antibody (8)

Cadherin 17 / CDH17 cDNA Clone (52)

NM_004063.2
NM_019753.4
NM_053977.2
XM_002805447.1

Cadherin 17 / CDH17 Lysate (3)

Cadherin 17 / CDH17 Related Research Area

Cadherin 17 / CDH17 Background

Cadherin-17 or LI-cadherin is a member of the cadherin superfamily, genes encoding calcium-dependent, membrane-associated glycoproteins. Cadherin-17/LI-cadherin is a cadherin-like protein consisting of an extracellular region, 7 cadherin domains, and a transmembrane region but lacking the conserved cytoplasmic domain. The protein is a component of the gastrointestinal tract and pancreatic ducts, acting as an intestinal proton-dependent peptide transporter in the first step in oral absorption of many medically important peptide-based drugs. The protein may also play a role in the morphological organization of liver and intestine. Alternative splicing of the encoding gene results in multiple transcript variants. Cadherin-17/LI-cadherin preferentially interact with themselves in a homophilic manner in connecting cells. Cadherin-17 may thus contribute to the sorting of heterogeneous cell types and have a role in the morphological organization of liver and intestine. It's also involved in intestinal peptide transport. Experiments have reported the association between Cadherin-17/LI-cadherin and gastric cancer. Cadherin-17/LI-cadherin expression was detected in 63/94 of gastric adenocarcinomas in addition to intestinal metaplasia. The expression of Cadherin-17 tended to be associated with intestinal type carcinoma, and carcinomas with Cadherin-17 expression was significantly more frequent in advanced stage cases than in early stage. Cadherin-17 is also a useful immunohistochemical marker for diagnosis of adenocarcinomas of the digestive system.

Cadherin 17 / CDH17 References

  • Liu LX, et al. (2009) Targeting cadherin-17 inactivates Wnt signaling and inhibits tumor growth in liver carcinoma. Hepatology. 50(5): 1453-63.
  • Ito R, et al. (2005) Clinicopathological significant and prognostic influence of cadherin-17 expression in gastric cancer. Virchows Arch. 447(4): 717-22.
  • Horsfield J, et al. (2002) Cadherin-17 is required to maintain pronephric duct integrity during zebrafish development. Mech Dev. 115(1-2): 15-26.