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Крыса CTHRC1 Джин клон кДНК в вектор клонирования

ПаспортОбзорыСвязанные продуктыПротоколы
Rat CTHRC1 Информация о продукте «Клон cDNA»
Gene_bank_ref_id:NM_001271300.1
Размер кДНК:693bp
Описание кДНК:Full length Clone DNA of Rattus norvegicus collagen triple helix repeat containing 1.
Синоним гена:Cthrc1
Виды:Rat
переносчик:pUC19 Vector
Plasmid:cpUC19-ratCthrc1
Участок рестрикции:
Последовательность меток:
Описание последовательности:Identical with the Gene Bank Ref. ID sequence except for the point mutations: 534T>C not causing the amino acid variation; 382T>C (F128L).
Sequencing primers:M13-47 and RV-M
Promoter:
Application:
Antibiotic in E.coli:Ampicilin
Antibiotic in mammalian cell:
Shipping_carrier:Each tube contains lyophilized plasmid.
Склад:The lyophilized plasmid can be stored at room temperature for three months.
Rat CTHRC1 Gene Plasmid Map
Rat CTHRC1 Gene cDNA Clone (full-length ORF Clone)
pUC19 vector Vector Information:

pUC19 is a small, high-copy number E. coli plasmid cloning vector, of which multiple cloning sites as shown below. The molecule is a small double-stranded circle, 2686 base pairs in length. pUC19 encodes the N-terminal fragment of b-galactosidase (lacZa), which allows for blue/white colony screening (i.e., a-complementation), as well as a pUC origin of replication.

pUC19 vector Usage Suggestion:

The coding sequence can be amplified by PCR with M13-47 and RV-M primers.

Vector Sequence Download
Крыса CTHRC1 Джин клон кДНК в вектор клонирования on other vectors
Крыса CTHRC1 Джин ORF экспрессии кДНК клона плазмиды, C-GFPSpark МеткаRG80712-ACGRBS15400
Крыса CTHRC1 Джин ORF экспрессии кДНК клона плазмиды, C-OFPSpark МеткаRG80712-ACRRBS15400
Крыса CTHRC1 Джин ORF экспрессии кДНК клона плазмиды, C-Flag МеткаRG80712-CFRBS13340
Крыса CTHRC1 Джин ORF экспрессии кДНК клона плазмиды, C-His МеткаRG80712-CHRBS13340
Крыса CTHRC1 Джин ORF экспрессии кДНК клона плазмиды, C-Myc МеткаRG80712-CMRBS13340
Крыса CTHRC1 Джин ORF экспрессии кДНК клона плазмиды, C-HA МеткаRG80712-CYRBS13340
Крыса CTHRC1 Джин ORF экспрессии кДНК клона плазмиды, N-Flag МеткаRG80712-NFRBS13340
Крыса CTHRC1 Джин ORF экспрессии кДНК клона плазмиды, N-His МеткаRG80712-NHRBS13340
Крыса CTHRC1 Джин ORF экспрессии кДНК клона плазмиды, N-Myc МеткаRG80712-NMRBS13340
Крыса CTHRC1 Джин ORF экспрессии кДНК клона плазмиды, N-HA МеткаRG80712-NYRBS13340
Крыса CTHRC1 Джин клон кДНК в вектор клонированияRG80712-URBS5130
Крыса CTHRC1 Джин ORF экспрессии кДНК клона плазмидыRG80712-UTRBS13340
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Product nameProduct name
Фон

Collagen triple helix repeat-containing protein 1, also known as Protein NMTC1, and CTHRC1, is a secreted protein that is glycosylated and highly conserved from lower chordates to mammals. CTHRC1 expression was not detectable in normal arteries. However, it is transiently expressed in the arterial wall in response to injury where it may contribute to vascular remodeling by limiting collagen matrix deposition and promoting cell migration. A short collagen motif with 12 Gly-X-Y repeats appears to be responsible for trimerization of the CTHRC1 protein and this renders the molecule susceptible to cleavage by collagenase. CTHRC1 overexpression caused a dramatic reduction in collagen type I mRNA and protein levels. Currently available data indicate that Cthrc1 expression in vascular cells regulates transforming growth factor beta responsiveness, thereby impacting transforming growth factor beta target genes, including collagens. Additionally, CTHRC1 increases bone mass as a positive regulator of osteoblastic bone formation and offers an anabolic approach for the treatment of osteoporosis.

Ссылки
  • Pyagay P, et al. (2005) Collagen triple helix repeat containing 1, a novel secreted protein in injured and diseased arteries, inhibits collagen expression and promotes cell migration. Circ Res. 96(2): 261-8.
  • Durmus T, et al. (2006) Expression analysis of the novel gene collagen triple helix repeat containing-1 (Cthrc1). Gene Expr Patterns. 6(8): 935-40.
  • LeClair R, et al. (2007) The role of collagen triple helix repeat containing 1 in injured arteries, collagen expression, and transforming growth factor beta signaling. Trends Cardiovasc Med. 17(6): 202-5.
  • Kimura H, et al. (2008) Cthrc1 is a positive regulator of osteoblastic bone formation. PLoS One. 3(9): e3174.
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    Каталог: RG80712-U
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