NY-ESO-1 cDNA ORF Clone in Cloning Vector, Human General Information
Identical with the Gene Bank Ref. ID sequence.
Full length Clone DNA of Human cancer/testis antigen 1A.
SP6 and T7 or M13-47 and RV-M
The plasmid is confirmed by full-length sequencing.
Antibiotic in E.coli
Storage & Shipping
Each tube contains lyophilized plasmid.
The lyophilized plasmid can be stored at ambient temperature for three months.
**Sino Biological guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories.**
NY-ESO-1 cDNA ORF Clone in Cloning Vector, Human Alternative Names
CT6.1 cDNA ORF Clone, Human;ESO1 cDNA ORF Clone, Human;LAGE-2 cDNA ORF Clone, Human;LAGE2A cDNA ORF Clone, Human;NY-ESO-1 cDNA ORF Clone, Human
NY-ESO-1 Background Information
NY-ESO-1 is another well-characterized CT antigen that appears to be the most immunogenic CT antigen known to date. Integrated humoral and cellular immune response against NY-ESO-1 are frequently observed in patients with tumors with NY-ESO-1 expression. As a member of CT antigens, NY-ESO-1 is expressed in a variety of malignant neoplasms, including melanomas, and esophageal, breast, prostate, urinary tract, ovarian, and lung cancers. Recently, immunohistochemical and molecular analytical approaches for the detection of NY-ESO-1 expression were compared, defining the reliability of each method. However, its clinical significance, e.g. in prognosis, in lung cancer is unclear.
Immune Checkpoint Immunotherapy Cancer Immunotherapy Targeted Therapy
cancer/testis antigen 1A
Yoshida N, Abe H, Ohkuri T, et al. Expression of the MAGE-A4 and NY-ESO-1 cancer-testis antigens and T cell infiltration in non-small cell lung carcinoma and their prognostic significance[J]. International journal of oncology, 2006, 28(5): 1089-1098.