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Человек CDNF/ARMETL1 Джин клон кДНК в вектор клонирования

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Human CDNF Информация о продукте «Клон cDNA»
Gene_bank_ref_id:NM_001029954.2
Размер кДНК:564bp
Описание кДНК:Full length Clone DNA of Homo sapiens cerebral dopamine neurotrophic factor.
Синоним гена:ARMETL1
Виды:Human
переносчик:pGEM-T Vector
Plasmid:pGEM-CDNF
Участок рестрикции:
Последовательность меток:
Описание последовательности:Identical with the Gene Bank Ref. ID sequence.
Sequencing primers:SP6 and T7 or M13-47 and RV-M
Promoter:
Application:
Antibiotic in E.coli:
Antibiotic in mammalian cell:
Shipping_carrier:Each tube contains lyophilized plasmid.
Склад:The lyophilized plasmid can be stored at room temperature for three months.
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pGEM-T Vector Information

The pGEM-T is 3kb in length, and contains the amplicin resistance gene, conferring selection of the plasmid in E. coli, and the ori site which is the bacterial origin of replication. The plasmid has multiple cloning sites as shown below. The coding sequence was inserted by TA cloning. Many E. coli strains are suitable for the propagation of this vector including JM109, DH5α and TOP10.

pGEM-T Simple Usage Suggestion:

The coding sequence can be easily obtained by digesting the vector with proper restriction enzyme(s). The coding sequence can also be amplified by PCR with M13 primers, or primer pair SP6 and T7.

Vector Sequence Download
Человек CDNF/ARMETL1 Джин клон кДНК в вектор клонирования on other vectors
Человек CDNF/ARMETL1 Джин ORF экспрессии кДНК клона плазмиды, C-GFPSpark МеткаHG15691-ACGRBS15400
Человек CDNF/ARMETL1 Джин ORF экспрессии кДНК клона плазмиды, C-OFPSpark МеткаHG15691-ACRRBS15400
Человек CDNF/ARMETL1 Джин ORF экспрессии кДНК клона плазмиды, C-Flag МеткаHG15691-CFRBS13340
Человек CDNF/ARMETL1 Джин ORF экспрессии кДНК клона плазмиды, C-His МеткаHG15691-CHRBS13340
Человек CDNF/ARMETL1 Джин ORF экспрессии кДНК клона плазмиды, C-Myc МеткаHG15691-CMRBS13340
Человек CDNF/ARMETL1 Джин ORF экспрессии кДНК клона плазмиды, C-HA МеткаHG15691-CYRBS13340
Человек CDNF/ARMETL1 Джин ORF экспрессии кДНК клона плазмиды, N-Flag МеткаHG15691-NFRBS13340
Человек CDNF/ARMETL1 Джин ORF экспрессии кДНК клона плазмиды, N-His МеткаHG15691-NHRBS13340
Человек CDNF/ARMETL1 Джин ORF экспрессии кДНК клона плазмиды, N-Myc МеткаHG15691-NMRBS13340
Человек CDNF/ARMETL1 Джин ORF экспрессии кДНК клона плазмиды, N-HA МеткаHG15691-NYRBS13340
Человек CDNF/ARMETL1 Джин ORF экспрессии кДНК клона плазмидыHG15691-UTRBS13340
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Фон

Cerebral Dopamine Neurotrophic Factor (CDNF), also known as ARMETL1 (ARMET-like protein 1), is a secreted protein with eight conserved cysteine residues, predicting a unique protein fold and defining a new, evolutionarily conserved protein family. CDNF is a novel neurotrophic factor with strong trophic activity on dopaminergic neurons comparable to that of glial cell line-derived neurotrophic factor (GDNF). CDNF/ARMETL1 is a evolutionary conserved protein which can protect and restore the function of dopaminergic neurons in the rat model of Parkinson's disease, suggesting that CDNF might be beneficial for the treatment of Parkinson's disease. CDNF is widely expressed in neurons in several brain regions including cerebral cortex, hippocampus, substantia nigra, striatum and cerebellum. Human CDNF is glycosylated and secreted from transiently transfected cells. CDNF promotes the survival, growth, and function of dopamine-specific neurons and is expressed in brain regions that undergo cocaine-induced neuroplasticity.

Ссылки
  • Choi JM, et al. (2011) Analysis of mutations and the association between polymorphisms in the cerebral dopamine neurotrophic factor (CDNF) gene and Parkinson disease. Neurosci Lett. 493(3): 97-101.
  • Sun ZP, et al. (2011) Intracellular trafficking and secretion of cerebral dopamine neurotrophic factor in neurosecretory cells. J Neurochem. 117(1): 121-32.
  • Lohoff FW, et al. (2009) Association analysis between polymorphisms in the conserved dopamine neurotrophic factor (CDNF) gene and cocaine dependence. Neurosci Lett. 453(3): 199-203.
  • Lindholm P, et al. (2007) Novel neurotrophic factor CDNF protects and rescues midbrain dopamine neurons in vivo. Nature. 448(7149): 73-7.
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    Каталог: HG15691-G
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