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MCP-1/CCL2  Белок

All CCL2 Reagents

Хозяин экспрессии: Yeast  
10134-H08Y-50
10134-H08Y-20
50 µg 
20 µg 
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Хозяин экспрессии: Baculovirus-Insect cells  
50368-M08B-50
50368-M08B-20
50 µg 
20 µg 
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MCP-1/CCL2 Related Area

MCP-1/CCL2 Связанные пути

MCP-1/CCL2 Краткая информация и сведения о белках

MCP-1/CCL2 Фон

Структура подгруппы: Monomer or homodimer; in equilibrium. Binds to CCR2 and CCR4. Is tethered on endothelial cells by glycosaminoglycan (GAG) side chains of proteoglycans. {ECO:0000269|PubMed:8898111}.
Субклеточное местоположение: Secreted.
Индукция: Up-regulated upon hypertonic conditions. {ECO:0000269|PubMed:23233732}.
Посттрансляционный: Processing at the N-terminus can regulate receptor and target cell selectivity. Deletion of the N-terminal residue converts it from an activator of basophil to an eosinophil chemoattractant.
Сходство последовательностей: Belongs to the intercrine beta (chemokine CC) family. {ECO:0000305}.
General information above from UniProt

Monocyte chemoattractant protein 1 (MCP-1), also called CCL2, belongs to a group of CC chemokines located in chromosome 17q11.2. MCP-1 protein interacts with chemokine C-C motif receptor 2 (CCR2) to activate and recruit monocytes, macrophages, CD4+ T cells and immature dendritic cells to the site of infection [7–9]. The presence of MCP-1 protein in an adequate concentration is important for granuloma formation and M. tuberculosis clearance.

Immune Checkpoint   Immunotherapy   Cancer Immunotherapy   Targeted Therapy

MCP-1/CCL2 Альтернативное название

MCP-1/CCL2 Связанные исследования

Внимание: все продукты «ПРЕДНАЗНАЧЕНЫ ИСКЛЮЧИТЕЛЬНО ДЛЯ ИССЛЕДОВАНИЙ И НЕ ПРЕДНАЗНАЧЕНЫ ДЛЯ ДИАГНОСТИКИ ИЛИ ТЕРАПЕВТИЧЕСКОГО ЛЕЧЕНИЯ».