BPHL (Protein | Antibody | cDNA Clone | ELISA Kit)

All BPHL reagents are produced in house and quality controlled, including 1 BPHL Antibody, 41 BPHL Gene, 1 BPHL IP Kit, 1 BPHL Protein, 1 BPHL qPCR. All BPHL reagents are ready to use.

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BPHL Related Research Area

BPHL Background

BPHL is a member of the serine protease family. BPHL is expressed large quantities in liver and kidney and in minor quantities in heart, intestine and skeletal muscle. BPHL is a specific alpha-amino acid ester hydrolase that prefers small, hydrophobic, and aromatic side chains and does not have a stringent requirement for the leaving group other than preferring a primary alcohol. It catalyzes the hydrolytic activation of amino acid ester prodrugs of nucleoside analogs such as valacyclovir and valganciclovir. BPHL also activates valacyclovir to acyclovir. It may play a role in detoxification processes.

BPHL References

  • Lai L. et al., 2008, J Biol Chem. 283 (14): 9318-27.
  • Davila S. et al., 2010, Genes Immun. 11 (3): 232-8.
  • Hendrickson SL. et al., 2010, PLoS One. 5 (9): e12862.