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ANTXR2 / CMG2  Белок

All ANTXR2  Reagents

Хозяин экспрессии: Human Cells  
15762-H02H-50
15762-H02H-100
50 µg 
100 µg 
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Хозяин экспрессии: Human Cells  
51131-M02H-50
51131-M02H-100
50 µg 
100 µg 
Add to Cart
  • Slide 1
Хозяин экспрессии: Human Cells  
51131-M08H-50
51131-M08H-100
50 µg 
100 µg 
Add to Cart
  • Slide 1

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ANTXR2 / CMG2 Related Area

ANTXR2 / CMG2 Связанные пути

    ANTXR2 / CMG2 Краткая информация и сведения о белках

    ANTXR2 / CMG2 Фон

    Структура подгруппы: Binds laminin, and possibly also collagen type IV. Binds to the protective antigen (PA) of Bacillus anthracis in a divalent cation-dependent manner, with the following preference: calcium > manganese > magnesium > zinc. Binding of PA leads to heptamerization of the receptor-PA complex.
    Домен: Binding to PA seems to be effected through the VWA domain.
    Субклеточное местоположение: Isoform 1: Cell membrane; Single-pass type I membrane protein. Note=Expressed at the cell surface.; Isoform 2: Endoplasmic reticulum membrane; Single-pass type I membrane protein. Note=Expressed predominantly within the endoplasmic reticulum and not at the plasma membrane.; Isoform 3: Secreted.
    Специфика ткани: Expressed in prostate, thymus, ovary, testis, pancreas, colon, heart, kidney, lung, liver, peripheral blood leukocytes, placenta, skeletal muscle, small intestine and spleen. {ECO:0000269|PubMed:14508707}.
    Степень заражения: DISEASE: Hyaline fibromatosis syndrome (HFS) [MIM:228600]: An autosomal recessive syndrome characterized by abnormal growth of hyalinized fibrous tissue usually affecting subcutaneous regions on the scalp, ears, neck, face, hands, and feet. The lesions appear as pearly papules or fleshy nodules. Additional features include gingival hypertrophy, progressive joint contractures resulting in severe limitation of mobility, osteopenia, and osteoporosis. Disease severity is variable. Some individuals manifest symptoms in infancy and have additional visceral or systemic involvement. Hyaline deposits in multiple organs, recurrent infections and intractable diarrhea often lead to early death. Surviving children may suffer from severely reduced mobility due to joint contractures. Other patients have later onset of a milder disorder affecting only the face and digits. {ECO:0000269|PubMed:12973667, ECO:0000269|PubMed:14508707, ECO:0000269|PubMed:15725249}. Note=The disease is caused by mutations affecting the gene represented in this entry.
    Сходство последовательностей: Belongs to the ATR family. {ECO:0000305}.; Contains 1 VWFA domain. {ECO:0000255|PROSITE-ProRule:PRU00219}.
    General information above from UniProt

    ANTXR2 / CMG2 Альтернативное название

    HFS,ISH,JHF,CMG2,CMG-2, [homo-sapiens]
    anthrax toxin receptor 2,ANTXR2,CMG-2,CMG2,HFS,ISH,JHF,capillary morphogenesis gene 2 protein,capillary morphogenesis protein 2, [human]
    anthrax toxin receptor 2,Antxr2,2310046B19Rik,AW561899,CMG-2,CMG2,cI-35, [mouse]
    CMG2,CMG-2,cI-35,AW561899,2310046B19Rik, [mus-musculus]

    ANTXR2 / CMG2 Связанные исследования

    Внимание: все продукты «ПРЕДНАЗНАЧЕНЫ ИСКЛЮЧИТЕЛЬНО ДЛЯ ИССЛЕДОВАНИЙ И НЕ ПРЕДНАЗНАЧЕНЫ ДЛЯ ДИАГНОСТИКИ ИЛИ ТЕРАПЕВТИЧЕСКОГО ЛЕЧЕНИЯ».