ANTXR2 cDNA ORF Clone in Cloning Vector, Human

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ANTXR2 cDNA ORF Clone in Cloning Vector, Human: General Information

Gene
Species
Human
NCBI Ref Seq
RefSeq ORF Size
1470 bp
Sequence Description
Identical with the Gene Bank Ref. ID sequence except for the point mutation 1069 G/C resulting in the amino acid Ala substitution by Pro.
Description
Full length Clone DNA of Human anthrax toxin receptor 2.
Plasmid
Vector
Sequencing Primers
SP6 and T7 or M13-47 and RV-M
Quality Control
The plasmid is confirmed by full-length sequencing.
Screening
Antibiotic in E.coli
Ampicillin
Storage & Shipping
Shipping
Each tube contains lyophilized plasmid.
Storage
The lyophilized plasmid can be stored at ambient temperature for three months.

ANTXR2 cDNA ORF Neucleotide Sequence and Amino Acid Sequence Information

**Sino Biological guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories.**

ANTXR2 cDNA ORF Clone in Cloning Vector, Human: Alternative Names

CMG-2 cDNA ORF Clone, Human; CMG2 cDNA ORF Clone, Human; HFS cDNA ORF Clone, Human; ISH cDNA ORF Clone, Human; JHF cDNA ORF Clone, Human

ANTXR2 Background Information

Loss-of-function mutations in capillary morphogenesis gene 2 (CMG2/ANTXR2), a transmembrane surface protein, cause hyaline fibromatosis syndrome (HFS), a severe genetic disorder that is characterized by large subcutaneous nodules, gingival hypertrophy and severe painful joint contracture. Anthrax toxin causes anthrax pathogenesis and expression levels of ANTXR2 (anthrax toxin receptor 2) are strongly correlated with anthrax toxin susceptibility. A recent genome-wide association study or GWAS identified that anthrax roxin receptor 2 (ANTXR2) was one of the risk loci for ankylosing spondylitis (AS). Previous study also showed that ANTXR2 could potentially affect new bone formation. This study aimed to investigate the possible mechanisms of ANTXR2 involved in AS pathogenesis.
Full Name
anthrax toxin receptor 2
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