SARS-CoV-2 (2019-nCoV) Antigen Reagents

The ongoing pneumonia outbreak in the city of Wuhan is caused by a newly identified coronavirus SARS-CoV-2 (2019-nCoV), This new virus belongs to the Betacoronavirus Genus, which also includes SARS CoV (2003) and MERS CoV (2012). The sequence reveals that SARS-CoV-2 (2019-nCoV) is more similar to SARS-CoV (70% similarity) than to MERS-CoV (40%).

Same as all other coronaviruses, the genome of SARS-CoV-2 (2019-nCoV) encodes the spike protein, the envelope protein, the membrane protein, and the nucleocapsid protein.
Full List of SARS-CoV-2 (2019-nCoV) Antigens
The spike protein (S-protein) mediates receptor binding and membrane fusion. Spike protein contains two subunits, S1 and S2. S1 contains a receptor binding domain (RBD), which is responsible for recognizing and binding with the cell surface receptor. S2 subunit is the "stem" of the structure, which contains other basic elements needed for the membrane fusion. The spike protein is the common target for neutralizing antibodies and vaccines.
It’s been reported that SARS-CoV-2 (2019-nCoV) (ref.) can infect the human respiratory epithelial cells through interaction with the human ACE2 receptor. Indeed, the recombinant Spike protein can bind with recombinant ACE2 protein.

【Reference: Xintian Xu.Evolution of the novel coronavirus from the ongoing Wuhan outbreak and modeling of its spike protein for risk of human transmission.SCIENCE CHINA Life Sciences.2020】

The nucleocapsid Protein (N-protein) is the most abundant protein in coronavirus. The N-protein is a highly immunogenic phosphoprotein, and it is normally very conserved. The N protein of coronavirus is often used as a marker in diagnostic assays.

Sino Biological Inc. is dedicated to infectious disease research. The company started to develop relevant tools for nCOV research, including cDNA clones, antigens, and antibodies, immediately after the sequence is published. The recombinant antigens we provide include the full length S protein (ECD), the S1 subunit, the S2 subunit, the S1 RBD, and the N protein.

Sino Biological can also provide CRO service for proteins and antibodies.

Contact Us to Order:
Tel: 215-583-7898
Email:order_us@sinobiological.com
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Catalogue 40592-V05H
Product Name SARS-Cov-2 (2019-nCoV) Spike Protein (RBD, mFc Tag)
Molecule Spike
Purity > 95 % as determined by SDS-PAGE
Expression Host Human Cells
Catalogue 40591-V08H
Product Name SARS-Cov-2 (2019-nCoV) Spike Protein S1 (His Tag)
Molecule Spike
Purity > 90 % as determined by SDS-PAGE
Expression Host Human Cells
Catalogue 40591-V02H
Product Name SARS-Cov-2 (2019-nCoV) Spike Protein S1 (Fc Tag)
Molecule Spike
Purity > 85 % as determined by SDS-PAGE
Expression Host Human Cells
Catalogue 40591-V05H1
Product Name SARS-Cov-2 (2019-nCoV) Spike Protein S1 (mFc Tag)
Molecule Spike
Purity > 85 % as determined by SDS-PAGE
Expression Host Human Cells
Catalogue 40588-V08B
Product Name SARS-Cov-2 (2019-nCoV) Nucleocapsid Protein (His tag)
Molecule Nucleocapsid
Purity > 95 % as determined by SDS-PAGE
Expression Host Insect Cells
Catalogue 40589-V08B1
Product Name SARS-Cov-2 (2019-nCoV) Spike Protein (S1+S2, His tag)
Molecule Spike
Purity > 90 % as determined by SDS-PAGE
Expression Host Insect Cells
Catalogue 40590-V08B
Product Name SARS-Cov-2 (2019-nCoV) Spike Protein (S2 ECD, His tag)
Molecule Spike
Purity > 90 % as determined by SDS-PAGE
Expression Host Insect Cells
Catalogue 40591-V08B1
Product Name SARS-Cov-2 (2019-nCoV) Spike Protein (S1 subunit, His tag)
Molecule Spike
Purity > 90 % as determined by SDS-PAGE
Expression Host Insect Cells
Catalogue 40592-V08B
Product Name SARS-Cov-2 (2019-nCoV) Spike Protein (RBD, His tag)
Molecule Spike
Purity > 95 % as determined by SDS-PAGE
Expression Host Insect Cells
Catalogue 40150-R007
Product Name SARS-Cov-2 (2019-nCoV) Spike (S1 subunit) Antibody
Molecule Spike
Application ELISA
Type Rabbit MAb
Catalogue 40143-R019
Product Name SARS-CoV-2 (2019-nCoV) Nucleocapsid/ N Antibody
Molecule Nucleocapsid
Application WB, ELISA
Type Rabbit MAb
Description   Species More
CoV Nucleocapsid
2019-nCoV
  2019-nCoV

Catalog
Tag
Vector
CoV spike
2019-nCoV
  2019-nCoV

Catalog
Tag
Vector
CoV spike
2019-nCoV
  2019-nCoV

Catalog
Tag
Vector
CoV spike
2019-nCoV
  2019-nCoV

Catalog
Tag
Vector
CoV spike
2019-nCoV
  2019-nCoV

Catalog
Tag
Vector

Capacity of Viral Reagents Development

• 2009.5 Launched Recombinant Influenza A H5N1 Hemagglutinin Protein

• 2009.12 Launched Influenza A H5N1 HA ELISA Pair Set and H1N1 HA ELISA Pair Set

• 2012.12 Launched MERS-CoV Spike Protein(S1,S2,S-RBD),NP protein within 50 Days after Sequence Published.

• 2013.4 Completed R&D of H7N9 HA Protein & H7N9 NA Protein in 12 Days.

• 2013.10 Launched SARS CoV Spike Protein,NP Protein.

• 2014.2 Completed R&D of EBOV NP, GP, VP40, VP24 Proteins.

• 2016.6 Completed R&D of ZIKV Envelope, Membane protein in 14 Days.

• 2020.1 Completed R&D of SARS-CoV-2 (2019-nCoV) Viral Proteins (Spike, S1, S2, RBD protein) in 12 Days.

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